ArticleScience (New York, N.Y.)2017
UBE2O remodels the proteome during terminal erythroid differentiation.
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Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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105citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
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Who cites it
105 citing papers in PubMed, 175 citations in OpenAlex.
- Substrate biasing in UCHL5 proteoforms.bioRxiv : the preprint server for biology · 2026Article
- The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers.Nature communications · 2026Article
- Article
- Post-translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases.MedComm · 2026Review
- Ribosome-associated quality control and related mechanisms.Nature structural & molecular biology · 2026Review
- UBE2O as a key regulator of drug-induced erythropoiesis in the context of myelodysplastic syndromes.Blood advances · 2026Article
- Turnover of missense mutant cytosolic proteins proceeds in the absence of major quality control E3 ligases.microPublication biology · 2026Article
- Stage-specific TRIM10 expression regulates erythroid maturation.EMBO reports · 2025Article
- UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions.EMBO reports · 2025Article
- Comprehensive Phenotypic and Proteomic Analyses of Human Reticulocyte Maturation.Blood red cells & iron · 2025Article
- Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics.eLife · 2025Article
- Mycobacterium tuberculosis hijacks the UBE2O pathway to regulate host iron homeostasis.The Journal of clinical investigation · 2025Article
- Review
- Impact of protein degradation and cell growth on mammalian proteomes.bioRxiv : the preprint server for biology · 2025Article
- RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis.Research square · 2025Article
- Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.Nature cell biology · 2025Article
- Ribosome-associated proteins: unwRAPping ribosome heterogeneity in the twenty-first century.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.Molecular cell · 2025Article
- Lysine succinylation precisely controls normal erythropoiesis.Haematologica · 2025Article
- Succinyl-coenzyme A: a key metabolite and succinyl group donor in erythropoiesis.Haematologica · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Anthony T NguyenDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0181-4623
Miguel A PradoDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4914-1619
Paul J SchmidtDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Anoop K SendamaraiDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0476-5428
Joshua T Wilson-GradyDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6919-0410
Mingwei MinDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Dean R CampagnaDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3893-0257
Geng TianDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8807-5669
Yuan ShiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9993-0448
Verena DedererDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Mona KawanDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7789-2404
Nathalie KuehnleDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4668-8712
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4291-413X
Yu YaoDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9286-4014
Mitchell J WeissDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Monica J JusticeGenetics and Genome Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario M5G 0A4, Canada.ORCID 0000-0003-3562-2099
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7626-0034
Mark D FlemingDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. mark.fleming@childrens.harvard.edu daniel_finley@hms.harvard.edu.ORCID 0000-0003-0948-4024
Daniel FinleyDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. mark.fleming@childrens.harvard.edu daniel_finley@hms.harvard.edu.ORCID 0000-0003-2076-5863
Harvard University · USBoston Children's Hospital · USSt. Jude Children's Research Hospital · USHospital for Sick Children · CA
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MMUTATIONS IN DEVELOPMENTAL PATHWAYS BY ENU MUTAGENESISU01HD039372 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI JUSTICE, MONICA JEAN · 2000 to 2005
$17.3MGenetic analysis of mouse chromosome 11R01CA115503 · NCI · BAYLOR COLLEGE OF MEDICINE · PI JUSTICE, MONICA J. · 2006 to 2010
$2.6MA novel program of ubiquitination in global remodeling of the erythroid proteomeR01HL125710 · NHLBI · HARVARD MEDICAL SCHOOL · PI FINLEY, DANIEL J, FLEMING, MARK D · 2015 to 2018
$1.9MResolving the role of nicotine-mediated phosphorylation on pancreatic fibrosisK01DK098285 · NIDDK · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2013 to 2017
$638kUbiquitination in erythropoiesis and the pathophysiology of anemiaR21HL116210 · NHLBI · HARVARD MEDICAL SCHOOL · PI FINLEY, DANIEL J, FLEMING, MARK D · 2012 to 2013
$477kA ubiquitin-conjugating enzyme critical for terminal erythroid differentiationF30HL124980 · NHLBI · HARVARD MEDICAL SCHOOL · PI NGUYEN, ANTHONY TUAN · 2014 to 2015
$83kNCI NIH HHS R01 CA115503NHLBI NIH HHS F30 HL124980NHLBI NIH HHS R01 HL125710NHLBI NIH HHS R21 HL116210NICHD NIH HHS U01 HD039372NIDDK NIH HHS K01 DK098285NIGMS NIH HHS T32 GM007753
Abstract
During terminal differentiation, the global protein complement is remodeled, as epitomized by erythrocytes, whose cytosol is ~98% globin. The erythroid proteome undergoes a rapid transition at the reticulocyte stage; however, the mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear. We found that a mutation in the murine
Indexed as
UbiquitinationAnemiaAnemia, HypochromicAnimalsbeta-GlobinsErythrocytesErythroid CellsErythropoiesisHEK293 CellsHumansMiceMice, Inbred C57BLMice, Mutant StrainsMutationProteasome Endopeptidase ComplexProteomebeta-GlobinsProteasome Endopeptidase ComplexProteomeRibosomal ProteinsUbe2o protein, mouseUbiquitin-Conjugating Enzymes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.