ArticleBiologicals : journal of the International Association of Biological Standardization2017
Recovery and assessment of leukocytes from LR Express filters.
Article in Biologicals : journal of the International Association of Biological Standardization, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recovery efficiency and functional characterization of T cells and NK cells from leukocyte filters.Frontiers in medicine · 2025Article
- Evaluation of a New Method of Leukocyte Extractions from the Leukoreduction Filter.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- CD8+ Lymphocytes from Healthy Blood Donors Secrete Antiviral Levels of Interferon-Alpha.Viruses · 2023Article
- Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells.Gene therapy · 2022Article
- Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused byHuman gene therapy · 2020Article
- Optimizing the recovery of peripheral blood mononuclear cells trapped in leukoreduction filters - A comparison study.Hematology, transfusion and cell therapyArticle
- Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research.Hematology, transfusion and cell therapyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Leukocytes, or white blood cells, are used for a variety of investigational purposes and they offer advantages over laboratory-adapted cell lines. Leukocytes that are typically discarded by blood banks during the collection of red blood cells, platelets, and plasma can often be obtained for research use. However, the available leukocytes are frequently contained within a blood filtration device, such as the Terumo LR Express (TLRE) filter. In this study, procedures were evaluated for the ability to elute viable leukocytes from TLRE filters. The recovered leukocytes were assessed for composition, growth, and functionality. The large majority (>70%) of leukocytes were eluted with a single reverse-elution procedure and the recovered cells contained representative populations of the major leukocyte subsets. Purified T cells exhibited diverse T cell receptor repertoires, characteristic growth upon mitogen stimulation, and CD4
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