Evidence map›Paper›PMID 28774688›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2017

Prenatal exposure to drinking-water chlorination by-products, cytochrome P450 gene polymorphisms and small-for-gestational-age neonates.

Samuella G Bonou, Patrick Levallois, Yves Giguère, Manuel Rodriguez, Alexandre Bureau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Samuella G BonouDépartement de médecine sociale et préventive, Faculté de médecine, Université Laval, 1050 avenue de la Médecine, Québec, QC, G1V 0A6, Canada.
Patrick LevalloisDépartement de médecine sociale et préventive, Faculté de médecine, Université Laval, 1050 avenue de la Médecine, Québec, QC, G1V 0A6, Canada; Direction de la santé environnement et de toxicologie, Institut national de santé publique du Québec et Axe Santé des populations et pratiques optimales en santé, Centre de recherche du CHU de Québec, Québec, QC, G1V 7B3, Canada. Electronic address: Patrick.Levallois@msp.ulaval.ca.
Yves GiguèreDépartement de biologie moléculaire, de biochimie médicale et de pathologie, Faculté de médecine, Université Laval, Québec, QC, G1R 3S1, Canada; Axe de Reproduction, santé de la mère et de l'enfant, Centre de recherche du CHU de Québec, Québec, QC, GIL 3L5, Canada.
Manuel RodriguezÉcole supérieure d'aménagement du territoire and Chaire d'eau potable, Université Laval, Québec, QC, G1V 0A6, Canada.
Alexandre BureauDépartement de médecine sociale et préventive, Faculté de médecine, Université Laval, 1050 avenue de la Médecine, Québec, QC, G1V 0A6, Canada; Axe de recherche neurosciences cliniques et cognitives, Institut universitaire en santé mentale de Québec, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Québec, QC, G1V 0A6, Canada.
Université Laval · CAInstitut Universitaire en Santé Mentale de Québec · CA

Funding

CIHR MOP102708
6 · The paper itself

Abstract

Genetic susceptibility may modulate chlorination by-products (CBPs) effects on fetal growth, especially genes coding for the cytochrome P450 involved in the metabolism of CBPs and steroidogenesis. In a case-control study of 1432 mother-child pairs, we assessed the association between maternal and child single nucleotide polymorphisms (SNPs) within CYP1A2, CYP2A6, CYP2D6 and CYP17A1 genes and small-for-gestational-age neonates (SGA<10th percentile) as well as interaction between these SNPs and maternal exposure to trihalomethanes or haloacetic acids (HAAs) during the third trimester of pregnancy. Interactions were found between mother and neonate carrying CYP17A1 rs4919687A and rs743572G alleles and maternal exposure to total trihalomethanes or five regulated HAAs species. However, these interactions became non statistically significant after correction for multiple testing. There is some evidence, albeit weak, of a potential effect modification of the association between CBPs and SGA by SNPs in CYP17A1 gene. Further studies are needed to validate these observations.

Indexed as

DisinfectionHalogenationInfant, Small for Gestational AgeWater PurificationAdultCytochrome P-450 Enzyme SystemDrinking WaterFemaleGenotypeHumansInfant, NewbornPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsWater Pollutants, ChemicalCytochrome P-450 Enzyme SystemDrinking WaterWater Pollutants, ChemicalChlorination by-productsCYP17A1CYP1A2CYP2A6CYP2D6Gene-environment interactionIntra-uterine growth restrictionSingle nucleotide polymorphismSmall-for-gestational-age

Identifiers

PMID28774688
PMCPMC5677517
OpenAlexW2740673095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.