Evidence map›Paper›PMID 28774685›Full record

ArticleMedical engineering & physics2017

In vitro performance of a shape memory polymer foam-coated coil embolization device.

Anthony J Boyle, Mark A Wierzbicki, Scott Herting, Andrew C Weems, Adam Nathan, Wonjun Hwang, Duncan J Maitland

Open access · greenAbstract read
In one paragraph

Article in Medical engineering & physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Macrophage activation in response to shape memory polymer foam-coated aneurysm occlusion devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Advances in Biomaterials and Technologies for Vascular Embolization.Advanced materials (Deerfield Beach, Fla.) · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anthony J BoyleDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA; Shape Memory Medical, Inc., College Station, TX, USA.
Mark A WierzbickiDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA; Shape Memory Medical, Inc., College Station, TX, USA.
Scott HertingDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Andrew C WeemsDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Adam NathanDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Wonjun HwangShape Memory Medical, Inc., College Station, TX, USA.
Duncan J MaitlandDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: djmaitland@tamu.edu.
Texas A&M University · USShape Memory Medical (United States) · US

Funding

Shape Memory Polymer Embolic Foams for Treating Cerebrovascular AneurysmsU01NS089692 · NINDS · TEXAS ENGINEERING EXPERIMENT STATION · PI MAITLAND, DUNCAN J · 2015 to 2018
$2.5M
NINDS NIH HHS U01 NS089692
6 · The paper itself

Abstract

Intracranial saccular aneurysm treatment using endovascular embolization devices are limited by aneurysm recurrence that can lead to aneurysm rupture. A shape memory polymer (SMP) foam-coated coil (FCC) embolization device was designed to increase packing density and improve tissue healing compared to current commercial devices. FCC devices were fabricated and tested using in vitro models to assess feasibility for clinical treatment of intracranial saccular aneurysms. FCC devices demonstrated smooth delivery through tortuous pathways similar to control devices as well as greater than 10 min working time for clinical repositioning during deployment. Furthermore, the devices passed pilot verification tests for particulates, chemical leachables, and cytocompatibility. Finally, devices were successfully implanted in an in vitro saccular aneurysm model with large packing density. Though improvements and future studies evaluating device stiffness were identified as a necessity, the FCC device demonstrates effective delivery and packing performance that provides great promise for clinical application of the device in treatment of intracranial saccular aneurysms.

Indexed as

Mechanical PhenomenaPolymers3T3 CellsAnimalsCell SurvivalEmbolization, TherapeuticFeasibility StudiesIntracranial AneurysmMaterials TestingMiceTime FactorsPolymersAneurysmEmbolization coilShape memory polymerSMP foam

Identifiers

PMID28774685
PMCPMC5819332
OpenAlexW2740004426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.