Evidence map›Paper›PMID 28774613›Full record

ArticleJournal of environmental sciences (China)2017

Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity.

Justin A Pals, Elizabeth D Wagner, Michael J Plewa, Menghang Xia, Matias S Attene-Ramos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of environmental sciences (China), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 36 citations in OpenAlex.

  1. An Excelled Trifluorinated Probe for GPCR Conformational Quantification.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Justin A PalsDepartment of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.
Elizabeth D WagnerDepartment of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Safe Global Water Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Michael J PlewaDepartment of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Safe Global Water Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Menghang XiaNational Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, United States.
Matias S Attene-RamosDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, United States. Electronic address: attene@gwu.edu.
Milken Institute · USUniversity of Illinois Urbana-Champaign · USNational Center for Advancing Translational Sciences · US

Funding

Small molecule screening programZ01HG200319 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI AUSTIN, CHRISTOPHER P · 2004 to 2008
$32.3M
Intramural NIH HHS Z01 HG200319
6 · The paper itself

Abstract

Haloacetamides (HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an S

Indexed as

AcetamidesDisinfectantsDisinfectionDNA DamageDrinking WaterMutagensOxidation-ReductionOxidative StressSulfhydryl CompoundsWater Pollutants, ChemicalAcetamidesDisinfectantsDrinking WaterMutagensSulfhydryl CompoundsWater Pollutants, ChemicalDNA damageDrinking water disinfection byproductsHaloacetamideOxidative stressSoft electrophileToxicity

Identifiers

PMID28774613
PMCPMC6239421
OpenAlexW2614103536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.