Evidence map›Paper›PMID 28774464›Full record

ArticleJournal of neuroimmunology2017

Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives.

Albert M Anderson, Theresa N Schein, Aley Kalapila, Lillin Lai, Drenna Waldrop-Valverde, Raeanne C Moore, Donald Franklin, Scott L Letendre, Scott R Barnum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Albert M AndersonDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, United States. Electronic address: aande2@emory.edu.
Theresa N ScheinDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States.
Aley KalapilaDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Lillin LaiDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Drenna Waldrop-ValverdeEmory University School of Nursing, Atlanta, GA, United States.
Raeanne C MooreDepartment of Psychiatry, University of California at San Diego, La Jolla, CA, United States.
Donald FranklinDepartment of Psychiatry, University of California at San Diego, La Jolla, CA, United States.
Scott L LetendreDepartment of Psychiatry, University of California at San Diego, La Jolla, CA, United States; Department of Medicine, University of California at San Diego, La Jolla, CA, United States.
Scott R BarnumDepartment of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States.
Emory University · USUniversity of California, San Diego · USUniversity of Alabama at Birmingham · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Real-Time Mobile Assessment of Daily Functioning Among Older HIV-Infected AdultsK23MH107260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2015 to 2018
$927k
Study of zidovudine addition in HIV-associated neurocognitive disordersK23MH095679 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2013 to 2017
$899k
NIAID NIH HHS P30 AI050409NIMH NIH HHS K23 MH095679NIMH NIH HHS K23 MH107260NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

The soluble membrane attack complex (sMAC) represents the terminal product of the complement cascade. We enrolled 47 HIV+ adults (12 of whom underwent a second visit at least 24weeks after starting therapy) as well as 11 HIV negative controls. At baseline, cerebrospinal fluid (CSF) sMAC was detectable in 27.7% of HIV+ individuals. CSF sMAC correlated with CSF HIV RNA levels and was more likely to be detectable in HIV+ individuals on cART compared to HIV negative controls. In HIV+ participants, there were negative association trends between sMAC and neurocognitive performance but these did not reach statistical significance.

Indexed as

AdultAnti-Retroviral AgentsCD4-Positive T-LymphocytesCognition DisordersComplement Membrane Attack ComplexFemaleHIV-1HIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedRNAStatistics as TopicAnti-Retroviral AgentsComplement Membrane Attack ComplexRNAAcquired immunodeficiency syndromeComplementHuman immunodeficiency virusMembrane attack complexNeurocognitive disorder

Identifiers

PMID28774464
PMCPMC5682931
OpenAlexW2737152235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.