Evidence map›Paper›PMID 28774381›Full record

ArticleJournal of the American College of Cardiology2017

First-in-Human Closed-Chest Transcatheter Superior Cavopulmonary Anastomosis.

Kanishka Ratnayaka, John W Moore, Rodrigo Rios, Robert J Lederman, Sanjeet R Hegde, Howaida G El-Said

Abstract readCase Reports
In one paragraph

Article in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Interventions for adult congenital heart disease.Nature reviews. Cardiology · 2025
    Review
  4. Article
  5. Interventional cardiovascular magnetic resonance: state-of-the-art.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  6. Article
  7. Transcatheter Electrosurgery: A Narrative Review.Circulation. Cardiovascular interventions · 2023
    Review
  8. Transcatheter Electrosurgery: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020
    Review
  9. Review
  10. X-ray fused with MRI guidance of pre-selected transcatheter congenital heart disease interventions.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2019
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kanishka RatnayakaDivision of Cardiology, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California; Cardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Electronic address: kratnayaka@rchsd.org.
John W MooreDivision of Cardiology, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California.
Rodrigo RiosDivision of Cardiology, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California.
Robert J LedermanCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Sanjeet R HegdeDivision of Cardiology, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California.
Howaida G El-SaidDivision of Cardiology, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California.
University of California San Diego · USNational Heart Lung and Blood Institute · US

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
Real-time MRI guided cardiovascular interventionZIAHL005062 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2009 to 2025
$21.6M
Diagnostic and interventional cardiovascular catheterizationZIDHL006061 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$18.2M
MRI catheter design and fabricationZIAHL006041 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2014 to 2025
$12.2M
Intramural NIH HHS ZIA HL006040
6 · The paper itself

Abstract

backgroundIn the care of patients with congenital heart disease, percutaneous interventional treatments have supplanted many surgical approaches for simple lesions, such as atrial septal defect. By contrast, complex congenital heart defects continue to require open-heart surgery. In single-ventricle patients, a staged approach is employed, which requires multiple open-heart surgeries and significant attendant morbidity and mortality. A nonsurgical transcatheter alternative would be attractive.

objectivesThe authors sought to show the feasibility of catheter-only, closed-chest, large-vessel anastomosis (superior vena cava and pulmonary artery [PA] or bidirectional Glenn operation equivalent) in a patient.

methodsIn preclinical testing over a decade, the authors developed the techniques and technology needed for nonsurgical crossing from a donor (superior vena cava) to a recipient (PA) vessel and endovascular stent-based anastomosis of those blood vessels. The authors undertook this transcatheter approach for an adult with untreated congenital heart disease with severe cyanosis and significant surgical risk. They rehearsed the procedure step by step using contrast-enhanced cardiac computed tomography and a patient-specific 3-dimensional printed heart model.

resultsThe authors describe a first-in-human, fully percutaneous superior cavopulmonary anastomosis (bidirectional Glenn operation equivalent). The patient, a 35-year-old woman, was homebound due to dyspnea and worsening cyanosis. She was diagnosed with functional single ventricle and very limited pulmonary blood flow. The heart team believed surgical palliation conferred high operative risk due to the patient's complete condition. With the percutaneous procedure, the patient recovered uneventfully and remained improved clinically after 6 months.

conclusionsThis procedure may provide a viable alternative to one of the foundational open-heart surgeries currently performed to treat single-ventricle congenital heart disease.

Indexed as

AdultCardiac CatheterizationCardiac Surgical ProceduresFeasibility StudiesFemaleHeart Bypass, RightHeart Defects, CongenitalHeart VentriclesHumansImaging, Three-DimensionalPulmonary ArteryTomography, X-Ray ComputedVena Cava, Superioradult congenital heart diseasecatheterizationGlenn shuntimage-guided interventionsingle ventricletranscatheter electrosurgery

Identifiers

PMID28774381
PMCPMC5583645
OpenAlexW2741672692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.