Evidence map›Paper›PMID 28774351›Full record

ArticleJournal of the International Neuropsychological Society : JINS2018

Cross-Disorder Cognitive Impairments in Youth Referred for Neuropsychiatric Evaluation.

Alysa E Doyle, Pieter J Vuijk, Nathan D Doty, Lauren M McGrath, Brian L Willoughby, Ellen H O'Donnell, H Kent Wilson, Mary K Colvin, Deanna C Toner, Kelsey E Hudson and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The Tower of London task in children and adolescents with neuropsychiatric disorders.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. The Multiple Deficit Model: Progress, Problems, and Prospects.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2020
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Alysa E Doyle1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Pieter J Vuijk3Center for Genomic Medicine,Massachusetts General Hospital,Boston,Massachusetts.
Nathan D Doty1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Lauren M McGrath5Department of Psychology,University of Denver,Denver,Colorado.
Brian L Willoughby1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Ellen H O'Donnell1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
H Kent Wilson1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Mary K Colvin1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Deanna C Toner3Center for Genomic Medicine,Massachusetts General Hospital,Boston,Massachusetts.
Kelsey E Hudson3Center for Genomic Medicine,Massachusetts General Hospital,Boston,Massachusetts.
Jessica E Blais3Center for Genomic Medicine,Massachusetts General Hospital,Boston,Massachusetts.
Hillary L Ditmars3Center for Genomic Medicine,Massachusetts General Hospital,Boston,Massachusetts.
Stephen V Faraone6Departments of Psychiatry and Neuroscience and Physiology,SUNY Upstate Medical University,Syracuse,New York.
Larry J Seidman2Harvard Medical School,Boston,Massachusetts.
Ellen B Braaten1Department of Psychiatry,Massachusetts General Hospital,Boston,Massachusetts.
Massachusetts General Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · USSUNY Upstate Medical University · USUniversity of Denver · US

Funding

Psychosis risk variants and cognitive control in clinically-referred youthR03MH106862 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOYLE, ALYSA E · 2015 to 2016
$249k
NIMH NIH HHS R03 MH106862
6 · The paper itself

Abstract

objectivesStudies suggest that impairments in some of the same domains of cognition occur in different neuropsychiatric conditions, including those known to share genetic liability. Yet, direct, multi-disorder cognitive comparisons are limited, and it remains unclear whether overlapping deficits are due to comorbidity. We aimed to extend the literature by examining cognition across different neuropsychiatric conditions and addressing comorbidity.

methodsSubjects were 486 youth consecutively referred for neuropsychiatric evaluation and enrolled in the Longitudinal Study of Genetic Influences on Cognition. First, we assessed general ability, reaction time variability (RTV), and aspects of executive functions (EFs) in youth with non-comorbid forms of attention-deficit/hyperactivity disorder (ADHD), mood disorders and autism spectrum disorder (ASD), as well as in youth with psychosis. Second, we determined the impact of comorbid ADHD on cognition in youth with ASD and mood disorders.

resultsFor EFs (working memory, inhibition, and shifting/ flexibility), we observed weaknesses in all diagnostic groups when participants' own ability was the referent. Decrements were subtle in relation to published normative data. For RTV, weaknesses emerged in youth with ADHD and mood disorders, but trend-level results could not rule out decrements in other conditions. Comorbidity with ADHD did not impact the pattern of weaknesses for youth with ASD or mood disorders but increased the magnitude of the decrement in those with mood disorders.

conclusionsYouth with ADHD, mood disorders, ASD, and psychosis show EF weaknesses that are not due to comorbidity. Whether such cognitive difficulties reflect genetic liability shared among these conditions requires further study. (JINS, 2018, 24, 91-103).

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildCognitive DysfunctionComorbidityExecutive FunctionFemaleHumansIntelligenceLongitudinal StudiesMaleMood DisordersPsychotic DisordersReaction TimeADHDAutism spectrum disorderExecutive functionsMood disordersPsychosisReaction time variability (RTV)

Identifiers

PMID28774351
PMCPMC5789455
OpenAlexW2744791278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.