Evidence map›Paper›PMID 28774293›Full record

Observational studyBMC medicine2017

The clinical utility of the urine-based lateral flow lipoarabinomannan assay in HIV-infected adults in Myanmar: an observational study.

Swe Swe Thit, Ne Myo Aung, Zaw Win Htet, Mark A Boyd, Htin Aung Saw, Nicholas M Anstey, Tint Tint Kyi, David A Cooper, Mar Mar Kyi, Josh Hanson

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Swe Swe ThitUniversity of Medicine 2, Yangon, Myanmar.
Ne Myo AungUniversity of Medicine 2, Yangon, Myanmar.
Zaw Win HtetInsein General Hospital, Yangon, Myanmar.
Mark A BoydUniversity of Adelaide, Lyell McEwin Hospital, Adelaide, Australia.
Htin Aung SawUniversity of Medicine 2, Yangon, Myanmar.
Nicholas M AnsteyMenzies School of Health Research, Charles Darwin University, Darwin, Australia.
Tint Tint KyiInsein General Hospital, Yangon, Myanmar.
David A CooperThe Kirby Institute, University of New South Wales, Sydney, Australia.
Mar Mar KyiUniversity of Medicine 2, Yangon, Myanmar.
Josh HansonUniversity of Medicine 2, Yangon, Myanmar. jhanson@kirby.unsw.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of the point-of-care lateral flow lipoarabinomannan (LF-LAM) test may expedite tuberculosis (TB) diagnosis in HIV-positive patients. However, the test's clinical utility is poorly defined outside sub-Saharan Africa.

methodsThe study enrolled consecutive HIV-positive adults at a tertiary referral hospital in Yangon, Myanmar. On enrolment, patients had a LF-LAM test performed according to the manufacturer's instructions. Clinicians managing the patients were unaware of the LF-LAM result, which was correlated with the patient's clinical course over the ensuing 6 months.

resultsThe study enrolled 54 inpatients and 463 outpatients between July 1 and December 31, 2015. On enrolment, the patients' median (interquartile range) CD4 T-cell count was 270 (128-443) cells/mm

conclusionsThe LF-LAM test had limited clinical utility in the management of HIV-positive patients in this Asian referral hospital setting.

Indexed as

AdultCD4-Positive T-LymphocytesFemaleHIV InfectionsHumansLipopolysaccharidesMaleMyanmarOutpatientsPoint-of-Care SystemsProspective StudiesSensitivity and SpecificityTuberculosislipoarabinomannanLipopolysaccharidesClinical managementDiagnostic testHuman immunodeficiency virusLipoarabinomannanMyanmarTuberculosis

Identifiers

PMID28774293
PMCPMC5543584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.