ArticleThe American journal of psychiatry2017
Vulnerability for Alcohol Use Disorder and Rate of Alcohol Consumption.
Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178069 (Lactobacillus Rhamnosus GG), which is not on this map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lactobacillus Rhamnosus GG: A Novel Probiotic Therapy for Treating Alcohol Use Disorder
Who cites it
87 citing papers in PubMed, 140 citations in OpenAlex.
- N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- The effects of acute alcohol administration on circulating endocannabinoid levels in humans.Addiction biology · 2022Trial
- Reward drinking and naltrexone treatment response among young adult heavy drinkers.Addiction (Abingdon, England) · 2021Trial
- Alcohol effects on globus pallidus connectivity: Role of impulsivity and binge drinking.PloS one · 2020Trial
- Targeting neuroinflammation with minocycline in heavy drinkers.Psychopharmacology · 2019Trial
- The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory.Alcoholism, clinical and experimental research · 2019Trial
- Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures.Alcoholism, clinical and experimental research · 2019Trial
- Cued unpredictable intermittent access exacerbates loss of control over ethanol drinking.Neuropharmacology · 2026Article
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Cued unpredictable intermittent access exacerbates loss of control over ethanol drinking.bioRxiv : the preprint server for biology · 2026Article
- Screening for Major Depression and Alcohol Use Disorder in Laundromats As a New Setting for Community- Based Engagement and Intervention.Community mental health journal · 2026Article
- Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task.Experimental and clinical psychopharmacology · 2025Article
- Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers.Psychopharmacology · 2025Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Scientific reports · 2024Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Research square · 2024Article
- Trait impulsivity moderates rate of alcohol consumption in daily life.Addictive behaviors · 2024Article
- Cholinergic interneurons in the shell region of the nucleus accumbens regulate binge alcohol consumption: A chemogenetic and genetic lesion study.Alcohol, clinical & experimental research · 2024Article
- Initial evidence of delay discounting's predictive utility for alcohol self-administration in ecologically valid contexts among young adults who drink heavily.Drug and alcohol dependence · 2024Article
- Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access.Alcohol (Fayetteville, N.Y.) · 2024Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlthough several risk factors have been identified for alcohol use disorder, many individuals with these factors do not go on to develop the disorder. Identifying early phenotypic differences between vulnerable individuals and healthy control subjects could help identify those at higher risk. Binge drinking, defined as reaching a blood alcohol level of 80 mg%, carries a risk of negative legal and health outcomes and may be an early marker of vulnerability. Using a carefully controlled experimental paradigm, the authors tested the hypothesis that risk factors for alcohol use disorder, including family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would predict rate of binging during an individual alcohol consumption session.
methodThis cross-sectional study included 159 young social drinkers who completed a laboratory session in which they self-administered alcohol intravenously. Cox proportional hazards models were used to determine whether risk factors for alcohol use disorder were associated with the rate of achieving a binge-level exposure.
resultsA greater percentage of relatives with alcoholism (hazard ratio: 1.04, 95% CI=1.02-1.07), male sex (hazard ratio: 1.74, 95% CI=1.03-2.93), and higher impulsivity (hazard ratio: 1.17, 95% CI=1.00 to 1.37) were associated with a higher rate of binging throughout the session. Participants with all three risk factors had the highest rate of binging throughout the session compared with the lowest risk group (hazard ratio: 5.27, 95% CI=1.81-15.30).
conclusionsBinge drinking may be an early indicator of vulnerability to alcohol use disorder and should be carefully assessed as part of a thorough clinical evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.