ArticleMaterials (Basel, Switzerland)2016
Mechanical Characterization and Constitutive Modeling of Human Trachea: Age and Gender Dependency.
Article in Materials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Area of origin analysis for expirated patterns using HemoVision.Journal of forensic sciences · 2026Article
- Article
- Human airway material characterization via inverse finite element analysis and neural network surrogate.Biomechanics and modeling in mechanobiology · 2026Article
- Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.Frontiers in cell and developmental biology · 2026Review
- The Impact of Utilizing a Balancing Blindfold During Training on the Backward Running Technique in Experienced and Novice Male Handball Players.Biomimetics (Basel, Switzerland) · 2025Article
- Method for Targeted Cellular Seeding of Tubular Tissue-Engineered Scaffolds for Tracheal Regeneration Approaches.ACS biomaterials science & engineering · 2025Article
- Tissue-Engineered Tracheal Reconstruction.Biomimetics (Basel, Switzerland) · 2025Review
- Organic and Synthetic Substitutes in Tracheal Reconstruction: A Scoping Review (2015-2025).Bioengineering (Basel, Switzerland) · 2025Review
- The forgotten airway: central airway pathology in the ICU.Frontiers in medicine · 2025Review
- Psidium guajava L. phenolic compound-reinforced lamellar scaffold for tracheal tissue engineering.Drug delivery and translational research · 2024Article
- A novel ex vivo tracheobronchomalacia model for airway stent testing and in vivo model refinement.The Journal of thoracic and cardiovascular surgery · 2023Article
- Article
- Image-Based Numerical Analysis for Isolated Type II SLAP Lesions in Shoulder Abduction and External Rotation.Diagnostics (Basel, Switzerland) · 2023Article
- Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways.Respiratory research · 2023Article
- Bioengineering and Clinical Translation of Human Lung and its Components.Advanced biology · 2023Review
- A preliminary biomechanical study on trachea reconstruction surgery using the clavicular periosteum.Frontiers in bioengineering and biotechnology · 2023Article
- Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways.Advances in experimental medicine and biology · 2023Article
- Development and clinical translation of tubular constructs for tracheal tissue engineering: a review.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Matrix Description of Non-Linear Properties of Materials or Structural Components-Idea and Application Examples.Materials (Basel, Switzerland) · 2021Article
- A Standardised Approach to the Biomechanical Evaluation of Tracheal Grafts.Biomolecules · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tracheal disorders can usually reduce the free lumen diameter or wall stiffness, and hence limit airflow. Trachea tissue engineering seems a promising treatment for such disorders. The required mechanical compatibility of the prepared scaffold with native trachea necessitates investigation of the mechanical behavior of the human trachea. This study aimed at mechanical characterization of human tracheas and comparing the results based on age and gender. After isolating 30 human tracheas, samples of tracheal cartilage, smooth muscle, and connective tissue were subjected to uniaxial tension to obtain force-displacement curves and calculate stress-stretch data. Among several models, the Yeoh and Mooney-Rivlin hyperelastic functions were best able to describe hyperelastic behavior of all three tracheal components. The mean value of the elastic modulus of human tracheal cartilage was calculated to be 16.92 ± 8.76 MPa. An overall tracheal stiffening with age was observed, with the most considerable difference in the case of cartilage. Consistently, we noticed some histological alterations in cartilage and connective tissue with aging, which may play a role in age-related tracheal stiffening. No considerable effect of gender on the mechanical behavior of tracheal components was observed. The results of this study can be applied in the design and fabrication of trachea tissue engineering scaffolds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.