ArticleMaterials (Basel, Switzerland)2016
Higher Ratios of Hyaluronic Acid Enhance Chondrogenic Differentiation of Human MSCs in a Hyaluronic Acid-Gelatin Composite Scaffold.
Article in Materials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Polyelectrolyte Complex Hydrogels with Controlled Mechanics Affect Mesenchymal Stem Cell Differentiation Relevant to Growth Plate Injuries.Macromolecular bioscience · 2022Article
- Recent Developments and Current Applications of Organic Nanomaterials in Cartilage Repair.Bioengineering (Basel, Switzerland) · 2022Review
- Mussel-inspired extracellular matrix-mimicking hydrogel scaffold with high cell affinity and immunomodulation ability for growth factor-free cartilage regeneration.Journal of orthopaedic translation · 2022Article
- The investigation of diverse physiological and therapeutic impact of cellular-based products derived from human cumulus cells.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- TEMPO/TCC as a Chemo Selective Alternative for the Oxidation of Hyaluronic Acid.Molecules (Basel, Switzerland) · 2021Article
- Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell migration and alignment.Materials today. Bio · 2020Article
- Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis.International journal of molecular sciences · 2020Review
- Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks.Molecules (Basel, Switzerland) · 2020Review
- The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives.International journal of molecular sciences · 2020Review
- Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect.Journal of tissue engineering and regenerative medicine · 2019Article
- Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Compositional and structural analysis of glycosaminoglycans in cell-derived extracellular matrices.Glycoconjugate journal · 2019Article
- A MMP7-sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage.Journal of biomedical materials research. Part A · 2018Article
- Hybrid Protein-Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation.ACS omega · 2017Article
- Dual Function of Glucosamine in Gelatin/Hyaluronic Acid Cryogel to Modulate Scaffold Mechanical Properties and to Maintain Chondrogenic Phenotype for Cartilage Tissue Engineering.International journal of molecular sciences · 2016Article
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8 authors.
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Abstract
Mesenchymal stem cells (MSCs) seeded on specific carrier materials are a promising source for the repair of traumatic cartilage injuries. The best supportive carrier material has not yet been determined. As natural components of cartilage's extracellular matrix, hyaluronic acid and collagen are the focus of biomaterial research. In order to optimize chondrogenic support, we investigated three different scaffold compositions of a hyaluronic acid (HA)-gelatin based biomaterial.
methodsHuman MSCs (hMSCs) were seeded under vacuum on composite scaffolds of three different HA-gelatin ratios and cultured in chondrogenic medium for 21 days. Cell-scaffold constructs were assessed at different time points for cell viability, gene expression patterns, production of cartilage-specific extracellular matrix (ECM) and for (immuno-)histological appearance. The intrinsic transforming growth factor beta (TGF-beta) uptake of empty scaffolds was evaluated by determination of the TGF-beta concentrations in the medium over time.
resultsNo significant differences were found for cell seeding densities and cell viability. hMSCs seeded on scaffolds with higher ratios of HA showed better cartilage-like differentiation in all evaluated parameters. TGF-beta uptake did not differ between empty scaffolds.
conclusionHigher ratios of HA support the chondrogenic differentiation of hMSCs seeded on a HA-gelatin composite scaffold.
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