ArticleMaterials (Basel, Switzerland)2017
The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures.
Article in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Predicting Powder Blend Flowability from Individual Constituent Properties Using Machine Learning.Pharmaceutical research · 2025Article
- Complexities related to the amorphous content of lactose carriers.International journal of pharmaceutics: X · 2023Review
- Optimization of drying conditions for Jackfruit pulp using Refractance Window Drying technology.Food science & nutrition · 2022Article
- Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Packaging and Delivery of Asthma Therapeutics.Pharmaceutics · 2021Review
- Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis.Pharmaceutics · 2021Article
- Inhalable Nanocomposite Microparticles with Enhanced Dissolution and Superior Aerosol Performance.Molecular pharmaceutics · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The flowability and dispersion behavior are two important physicochemical properties of pharmaceutical formulations for dry powder inhalers (DPIs). They are usually affected by the environmental conditions, such as temperature and relative humidity (RH). However, very few studies have been focused on the relationship between the two properties and their dependence on RH during storage. In this research, model pharmaceutical formulations were prepared using mixtures of coarse and fine lactose. The fractions of fines in the mixtures were 0%, 5%, 10%, and 20%, respectively. These blends were stored at four different RH levels, 0%, 30%, 58%, and 85%, for 48 h. The FT4 Powder Rheometer was used to evaluate the powder flowability, and the Malvern Spraytec
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