ArticleMaterials (Basel, Switzerland)2017
Laser Sintered Magnesium-Calcium Silicate/Poly-ε-Caprolactone Scaffold for Bone Tissue Engineering.
Article in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Overview of porous magnesium-based scaffolds: development, properties and biomedical applications.Materials futures · 2025Review
- Osteoinductive potential of graphene and graphene oxide for bone tissue engineering: a comparative study.Journal of orthopaedic surgery and research · 2024Article
- Review
- Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering.Regenerative biomaterials · 2023Review
- Additive Manufactured Magnesium-Based Scaffolds for Tissue Engineering.Materials (Basel, Switzerland) · 2022Review
- Three-dimensional printing in the field of oral and maxillofacial surgery.National journal of maxillofacial surgery · 2022Review
- Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Cultured on Magnesium Oxide/Polycaprolactone Nanofibrous Scaffolds for Improving Bone Tissue Reconstruction.Advanced pharmaceutical bulletin · 2022Article
- Composite Fiber Spun Mat Synthesis and In Vitro Biocompatibility for Guide Tissue Engineering.Molecules (Basel, Switzerland) · 2021Article
- Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds.Materials (Basel, Switzerland) · 2021Article
- Scientometric Analysis and Systematic Review of Multi-Material Additive Manufacturing of Polymers.Polymers · 2021Review
- Advances in 3D Printing for Tissue Engineering.Materials (Basel, Switzerland) · 2021Review
- Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review.Molecular biotechnology · 2021Review
- Review
- The Applications of 3D Printing for Craniofacial Tissue Engineering.Micromachines · 2019Review
- 3D-Printed Bioactive Calcium Silicate/Poly-ε-Caprolactone Bioscaffolds Modified with Biomimetic Extracellular Matrices for Bone Regeneration.International journal of molecular sciences · 2019Article
- Therapeutic Metallic Ions in Bone Tissue Engineering: A Systematic Review of The Literature.Iranian journal of pharmaceutical research : IJPR · 2019Review
- Article
- PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications.Molecular biotechnology · 2018Review
- Recent Advances in Biomaterials for 3D Printing and Tissue Engineering.Journal of functional biomaterials · 2018Review
- 3D Printing-Encompassing the Facets of Dentistry.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we manufacture and analyze bioactive magnesium-calcium silicate/poly-ε-caprolactone (Mg-CS/PCL) 3D scaffolds for bone tissue engineering. Mg-CS powder was incorporated into PCL, and we fabricated the 3D scaffolds using laser sintering technology. These scaffolds had high porosity and interconnected-design macropores and structures. As compared to pure PCL scaffolds without an Mg-CS powder, the hydrophilic properties and degradation rate are also improved. For scaffolds with more than 20% Mg-CS content, the specimens become completely covered by a dense bone-like apatite layer after soaking in simulated body fluid for 1 day. In vitro analyses were directed using human mesenchymal stem cells (hMSCs) on all scaffolds that were shown to be biocompatible and supported cell adhesion and proliferation. Increased focal adhesion kinase and promoted cell adhesion behavior were observed after an increase in Mg-CS content. In addition, the results indicate that the Mg-CS quantity in the composite is higher than 10%, and the quantity of cells and osteogenesis-related protein of hMSCs is stimulated by the Si ions released from the Mg-CS/PCL scaffolds when compared to PCL scaffolds. Our results proved that 3D Mg-CS/PCL scaffolds with such a specific ionic release and good degradability possessed the ability to promote osteogenetic differentiation of hMSCs, indicating that they might be promising biomaterials with potential for next-generation bone tissue engineering scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.