Evidence map›Paper›PMID 28772390›Full record

ArticleMaterials (Basel, Switzerland)2017

Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration.

Manabu Tanaka, Hisao Haniu, Takayuki Kamanaka, Takashi Takizawa, Atsushi Sobajima, Kazushige Yoshida, Kaoru Aoki, Masanori Okamoto, Hiroyuki Kato, Naoto Saito

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  9. Article
  10. Applications of Carbon Nanotubes in Bone Regenerative Medicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Manabu TanakaDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. m990054e@gmail.com.
Hisao HaniuDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. hhaniu@shinshu-u.ac.jp.
Takayuki KamanakaDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. kam17@hotmail.co.jp.
Takashi TakizawaDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. takashitak@shinshu-u.ac.jp.
Atsushi SobajimaDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. soba@shinshu-u.ac.jp.
Kazushige YoshidaDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. gooddays83@yahoo.co.jp.
Kaoru AokiDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. kin29men@shinshu-u.ac.jp.
Masanori OkamotoDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. masanori_ckmt@ybb.ne.jp.
Hiroyuki KatoDepartment of Orthopaedic Surgery, School of Medicine, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. hirokato@shinshu-u.ac.jp.
Naoto SaitoInstitute for Biomedical Sciences, Shinshu University, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan. saitoko@shinshu-u.ac.jp.
Shinshu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unidirectional porous hydroxyapatite HAp (UDPHAp) is a scaffold with continuous communicated pore structure in the axial direction. We evaluated and compared the ability of the UDPHAp as a three-dimensional (3D) bone tissue engineering scaffold to the interconnected calcium porous HAp ceramic (IP-CHA). To achieve this, we evaluated in vitro the compressive strength, controlled rhBMP-2 release behavior, adherent cell morphology, cell adhesion manner, and cell attachment of UDPHAp. As a further in vivo experiment, UDPHAp and IP-CHA with rhBMP-2 were transplanted into mouse calvarial defects to evaluate their bone-forming ability. The Results demonstrated that the maximum compressive strengths of the UDPHAp was 7.89 ± 1.23 MPa and higher than that of IP-CHA (1.92 ± 0.53 MPa) (

Indexed as

regenerative medicinescaffoldunidirectional pore

Identifiers

PMID28772390
PMCPMC5344564
OpenAlexW2566958888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.