Evidence map›Paper›PMID 28772191›Full record

ReviewCurrent opinion in biotechnology2018

Synthetic genetic circuits in crop plants.

Orlando de Lange, Eric Klavins, Jennifer Nemhauser

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Can a plant biologist fix a thermostat?The New phytologist · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Biocircuits in plants and eukaryotic algae.Frontiers in plant science · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Application of the Safe-By-Design Concept in Crop Breeding Innovation.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Orlando de LangeUniversity of Washington, Department of Electrical Engineering, Seattle, WA, USA.
Eric KlavinsUniversity of Washington, Department of Electrical Engineering, Seattle, WA, USA.
Jennifer NemhauserUniversity of Washington, Department of Biology, Seattle, WA, USA. Electronic address: jn7@uw.edu.

Funding

Control of protein degradation dynamics in the auxin responseR01GM107084 · NIGMS · UNIVERSITY OF WASHINGTON · PI NEMHAUSER, JENNIFER L · 2014 to 2022
$2.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM107084
6 · The paper itself

Abstract

The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs to targeted genome modifications. Synthetic genetic circuits, a recent development, are combinations of regulatory and coding DNA introduced into a crop plant to achieve a desired function. Genetic circuits could accelerate crop improvement, allowing complex traits to be rationally designed and requisite DNA parts delivered directly into a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.

Indexed as

Gene Regulatory NetworksPlant BreedingCrops, AgriculturalGenetic EngineeringInventionsPlants, Genetically Modified

Identifiers

PMID28772191
PMCPMC6007868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.