Evidence map›Paper›PMID 28772035›Full record

ArticleESC heart failure2017

Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components.

Karin Macfelda, Barbara Kapeller, Alexander Holly, Bruno K Podesser, Udo Losert, Kersten Brandes, Peter Goettel, Johannes Mueller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Enhancing Drug Utilization EfficiencyFrontiers in bioengineering and biotechnology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Karin MacfeldaDepartment of Biomedical Research (Cell Biology), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Barbara KapellerDepartment of Biomedical Research (Cell Biology), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Alexander HollyDepartment of Biomedical Research (Cell Biology), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Bruno K PodesserDepartment of Biomedical Research (Cell Biology), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Udo LosertDepartment of Biomedical Research (Cell Biology), Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Kersten BrandesBerlin Heals, Knesebeckstrasse 59-61, 10719, Berlin, Germany.
Peter GoettelBerlin Heals, Knesebeckstrasse 59-61, 10719, Berlin, Germany.
Johannes MuellerBerlin Heals, Knesebeckstrasse 59-61, 10719, Berlin, Germany.
Medical University of Vienna · ATBerlin Heart (Germany) · DEEvangelische Hochschule Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBeyond the influence of stimulating devices on cardiac excitation, their use in treating patients with heart failure has positive effects on the myocardium at the molecular level. Electrical signals can induce a wide spectrum of effects in living tissue. Therefore, we sought to determine whether applying electrical microcurrent directly to failing hearts leads to functional improvement. METHODS AND

resultsSixteen male spontaneously hypertensive rats (SHRs) with heart failure underwent application of a patch electrode to the left ventricular epicardium and placement of a subcutaneous counter electrode. The electrode delivered a 0.35 μA microcurrent to nine of the SHRs for 45 ± 3 days; the other seven SHRs were used as controls. At baseline and before the SHRs were humanely put to death, we measured the left ventricular ejection fraction (LVEF) and the thickness of the LV posterior wall during systole and diastole (LVPWs/d). We used quantitative PCR to determine extracellular matrix parameters [collagen I-III, matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinases 3 (TIMP3), TIMP4, connexins (Cxs) 40/43/45, transforming growth factor (TGF)-β, and interleukin (IL)-6]. Among SHRs undergoing microcurrent application, LVEF normalized (mean decrease, 22.8%; P = 0.009), and LVPWs decreased (mean, 35.3%; P = 0.001). Compared with the control group, the SHRs receiving microcurrent exhibited a mean decrease in the gene expression of collagen I (10.6%, P = 0.003), TIMP3 (18.5%, P = 0.005), Cx43 (14.3%, P = 0.003), Cx45 (12.7%, P = 0.020), TGF-β (13.0%, P = 0.005), and IL-6 (53.7%, P = 0.000). Microcurrent application induced no changes in the expression of collagen III, MMP-2, MMP-9, TIMP4, or Cx40.

conclusionsApplying microcurrent to the LV epicardium of SHRs leads to statistically significant functional improvement and alterations in the levels of inflammatory and extracellular matrix components.

Indexed as

BioelectricCollagenElectrical stimulationExtracellular matrixHeart failureReverse remodelling

Identifiers

PMID28772035
PMCPMC5542736
OpenAlexW2729762003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.