Evidence map›Paper›PMID 28772028›Full record

ArticleESC heart failure2017

Comparative accuracy of NT-proBNP and MR-proANP for the diagnosis of acute heart failure in dyspnoeic patients.

Fabrice F Darche, Christian Baumgärtner, Moritz Biener, Matthias Müller-Hennessen, Mehrshad Vafaie, Vitali Koch, Kiril Stoyanov, Rasmus Rivinius, Hugo A Katus, Evangelos Giannitsis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Redefining biomarkers in heart failure.Heart failure reviews · 2018
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fabrice F DarcheDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Christian BaumgärtnerDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Moritz BienerDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Matthias Müller-HennessenDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Mehrshad VafaieDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Vitali KochDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Kiril StoyanovDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Rasmus Rivinius
Hugo A KatusDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Evangelos GiannitsisDepartment of Cardiology, Medical University Hospital Heidelberg, INF 410, D-69120, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo compare the performance of the natriuretic peptides (NPs) NT-proBNP and MR-proANP for the diagnosis of acute heart failure (AHF) in subsets of conditions potentially confounding the interpretation of NPs. METHODS AND

resultsWe studied 312 patients, presenting to the emergency department with new onset of dyspnoea or worsening of chronic dyspnoea within the last 2 weeks. Performance of NPs for the diagnosis of AHF was tested and compared using C-statistics in the entire cohort and in conditions previously described to confound interpretation of NPs such as older age, renal failure, obesity, atrial fibrillation or paced rhythm, and in the NT-proBNP grey zone. AHF was diagnosed in 139 patients. In the entire cohort, the diagnostic performance of NT-proBNP was comparable with that of MR-proANP. Receiver operating characteristic analysis demonstrated that optimal diagnostic cut-offs were higher in the presence of older age, kidney failure or rhythm disorder. However, there were no statistically relevant differences between the receiver operating characteristic curves analysed in the total population and those studied in the pre-specified subsets severe kidney failure, advanced age, obesity, atrial fibrillation and paced rhythm, and grey zone NT-proBNP values. Moreover, the diagnostic performance of NT-proBNP was comparable with that of MR-proANP in the subsets.

conclusionsThe performance of NT-proBNP and MR-proANP for AHF is comparable in the total population as well as in the subsets with potentially confounding characteristics such as older age, renal dysfunction, obesity, atrial fibrillation and paced rhythm, or those with NT-proBNP values in the grey zone.

Indexed as

AHFClinical subsetsMR-proANPNT-proBNPROC curve

Identifiers

PMID28772028
PMCPMC5542722
OpenAlexW2606817697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.