ArticleCell proliferation2017
Cellular behaviours of bone marrow-derived mesenchymal stem cells towards pristine graphene oxide nanosheets.
Article in Cell proliferation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Graphene oxide-modified PEEK composites: Properties and applications in orthopaedic repair - A review.Journal of orthopaedic translation · 2026Review
- Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis.Journal of materials science. Materials in medicine · 2025Article
- A Carbon-Based Nanomaterial with Dichotomous Effects: Antineoplastic on Oral Cancer Cells and Osteoinductive/Chondroinductive on Dental Pulp Stem Cells.Journal of functional biomaterials · 2025Article
- Single-layer graphene oxide nanosheets induce proliferation and Osteogenesis of single-cell hBMSCs encapsulated in Alginate Microgels.Scientific reports · 2024Article
- Non-Cytotoxic Graphene Nanoplatelets Upregulate Cell Proliferation and Self-Renewal Genes of Mesenchymal Stem Cells.International journal of molecular sciences · 2024Article
- The regulatory effect of TiOBMC oral health · 2024Article
- Applications of graphene oxide and reduced graphene oxide in advanced dental materials and therapies.Journal of Taibah University Medical Sciences · 2024Review
- Graphene oxide/ε-poly-L-lysine self-assembled functionalized coatings improve the biocompatibility and antibacterial properties of titanium implants.Frontiers in bioengineering and biotechnology · 2024Article
- Review
- Biocompatibility of graphene oxide nanosheets functionalized with various amino acids towards mesenchymal stem cells.Heliyon · 2023Article
- Graphene quantum dots enhance the osteogenic differentiation of PDLSCs in the inflammatory microenvironment.BMC oral health · 2023Article
- A Novel Zwitterionic Hydrogel Incorporated with Graphene Oxide for Bone Tissue Engineering: Synthesis, Characterization, and Promotion of Osteogenic Differentiation of Bone Mesenchymal Stem Cells.International journal of molecular sciences · 2023Article
- 3D-Printing Graphene Scaffolds for Bone Tissue Engineering.Pharmaceutics · 2022Review
- Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells.Molecules (Basel, Switzerland) · 2022Review
- Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications.Journal of nanostructure in chemistry · 2022Review
- Graphene-Based Nanomaterials for Dental Applications: Principles, Current Advances, and Future Outlook.Frontiers in bioengineering and biotechnology · 2022Review
- Ultrathin 2D Titanium Carbide MXene (TiAdvanced healthcare materials · 2021Article
- rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular RemodelingFrontiers in cardiovascular medicine · 2021Article
- Layer-Number-Dependent Effects of Graphene Oxide on the Pluripotency of Mouse Embryonic Stem Cells Through the Regulation of the Interaction Between the Extracellular Matrix and Integrins.International journal of nanomedicine · 2021Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGraphene oxide (GO), the derivative of graphene with unique properties, has attracted much attention for applications in dental implants. The aim of this study was, by two biomimetic cell culture methods, to investigate the quantitative relationship between the concentration of pristine GO nanosheets and their cellular behaviours towards bone marrow-derived mesenchymal stem cells (BMSCs). MATERIALS AND
methodsThe cells were firstly characterized according to their morphology, self-renewal capabilities and multipotency. Subsequently, adhesion density, proliferation, alkaline phosphatase activity and mineralization of BMSCs treated with various concentrations of GO were analysed. In addition, osteogenic-related proteins were measured for further verification of the GO-induced osteogenic differentiation.
resultsPristine GO nanosheets inhibited the proliferation of BMSCs at a high concentration of 10 μg/mL during the first 3 days with two seeding methods and facilitated proliferation of BMSCs at a low concentration of 0.1 μg/mL after 5 days with a sequential-seeding method compared to a co-seeding method. Analogously, osteogenic differentiation was promoted when BMSCs were treated with 0.1 μg/mL of GO. Both the proliferation and differentiation showed concentration-dependent behaviour. Interestingly, Wnt/β-catenin signalling pathway appeared to be involved in osteogenic differentiation induced by pristine GO nanosheets.
conclusionsPristine GO nanosheets at a concentration of 0.1 μg/mL provide benefits to promote BMSCs proliferation and osteogenesis under a sequential-seeding method, contributing to the use of GO for dental implantation.
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