ArticleThe Laryngoscope2018
Repairing the vibratory vocal fold.
Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Autologous fibroblasts for vocal scars and age-related atrophy: A randomized clinical trial.The Laryngoscope · 2020Trial
- Vocal Outcomes After Cell-Based Outer Vocal Fold Implant in Porcine Bilateral Vocal Fold Resection.The Laryngoscope · 2026Article
- Safety and Toxicity Evaluation of Stem Cell-Based Vocal Fold Implant in Swine.The Laryngoscope · 2026Article
- Vocal Fold Injury Produces Similar Biomechanical Outcomes in Male and Female Rabbits.Journal of voice : official journal of the Voice Foundation · 2024Article
- Cell-Based Outer Vocal Fold Replacement Both Treats and Prevents Vocal Fold Scarring in Rabbits.The Laryngoscope · 2024Article
- Ultrafast Laser Microlaryngeal Surgery for In Vivo Subepithelial Void Creation in Canine Vocal Folds.The Laryngoscope · 2023Article
- Tissue-engineered vocal fold replacement in swine: Methods for functional and structural analysis.PloS one · 2023Article
- A xenograft study of human adipose stromal cell-based vocal fold mucosal replacement in rabbits.Laryngoscope investigative otolaryngology · 2022Article
- Bioreactors for Vocal Fold Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
- Antifibrotic effects of Quercetin on TGF-β1-induced vocal fold fibroblasts.American journal of translational research · 2022Article
- Objective Assessment of Porcine Voice Acoustics for Laryngeal Surgical Modeling.Applied sciences (Basel, Switzerland) · 2021Article
- Unraveling the molecular pathobiology of vocal fold systemic dehydration using an in vivo rabbit model.PloS one · 2020Article
- Biocompatibility and Viscoelastic Properties of Injectable Resilin-Like Polypeptide and Hyaluronan Hybrid Hydrogels in Rabbit Vocal Folds.Regenerative engineering and translational medicine · 2019Article
- Motor endplate-expressing cartilage-muscle implants for reconstruction of a denervated hemilarynx.The Laryngoscope · 2019Article
- Individualized Patient Vocal Priorities for Tailored Therapy.Journal of speech, language, and hearing research : JSLHR · 2018Article
- Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits.The Annals of otology, rhinology, and laryngology · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
objectiveA vibratory vocal fold replacement would introduce a new treatment paradigm for structural vocal fold diseases such as scarring and lamina propria loss. This work implants a tissue-engineered replacement for vocal fold lamina propria and epithelium in rabbits and compares histology and function to injured controls and orthotopic transplants. Hypotheses were that the cell-based implant would engraft and control the wound response, reducing fibrosis and restoring vibration. STUDY
designTranslational research.
methodsRabbit adipose-derived mesenchymal stem cells (ASC) were embedded within a three-dimensional fibrin gel, forming the cell-based outer vocal fold replacement (COVR). Sixteen rabbits underwent unilateral resection of vocal fold epithelium and lamina propria, as well as reconstruction with one of three treatments: fibrin glue alone with healing by secondary intention, replantation of autologous resected vocal fold cover, or COVR implantation. After 4 weeks, larynges were examined histologically and with phonation.
resultsFifteen rabbits survived. All tissues incorporated well after implantation. After 1 month, both graft types improved histology and vibration relative to injured controls. Extracellular matrix (ECM) of the replanted mucosa was disrupted, and ECM of the COVR implants remained immature. Immune reaction was evident when male cells were implanted into female rabbits. Best histologic and short-term vibratory outcomes were achieved with COVR implants containing male cells implanted into male rabbits.
conclusionVocal fold cover replacement with a stem cell-based tissue-engineered construct is feasible and beneficial in acute rabbit implantation. Wound-modifying behavior of the COVR implant is judged to be an important factor in preventing fibrosis. LEVEL OF EVIDENCE: NA. Laryngoscope, 128:153-159, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.