ArticlePloS one2017
Inverse association of resistin with physical activity in the general population.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Adipocytokine plasma level changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women.European journal of nutrition · 2023Trial
- Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty.Lipids in health and disease · 2021Trial
- Trial
- Adipocytokine Profiles in Type 2 Diabetes Mellitus and Autoimmune Thyroid Disease: Associations With Metabolic and Hormonal Parameters.Physiological research · 2026Article
- Higher serum resistin levels and increased frailty risk in older adults: Implications beyond metabolic function.The journal of nutrition, health & aging · 2025Article
- Effect of physical activity levels on blood lipids, insulin resistance, and adipokines in children with obesity.Physical activity and nutrition · 2023Article
- Ideal Cardiovascular Health and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Article
- Effect of Lifestyle Interventions during Pregnancy on Maternal Leptin, Resistin and Offspring Weight at Birth and One Year of Life.Biomedicines · 2023Article
- Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors.International journal of molecular sciences · 2023Review
- Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study.PloS one · 2023Article
- Resistin as a risk factor for all-cause (and cardiovascular) death in the general population.Scientific reports · 2022Article
- Irisin is more strongly associated with leisure-time physical activity than resistin and high-density lipoprotein cholesterol are.Journal of exercise science and fitness · 2022Article
- Article
- The Associations of Body Image Perception with Serum Resistin Levels in Highly Trained Adolescent Estonian Rhythmic Gymnasts.Nutrients · 2021Article
- Adipocytokines: Are they the Theory of Everything?Cytokine · 2020Review
- The Effect of the Ultra-Marathon Run at a Distance of 100 Kilometers on the Concentration of Selected Adipokines in Adult Men.International journal of environmental research and public health · 2020Article
- Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement.Lipids in health and disease · 2019Article
- An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis.Mediators of inflammation · 2019Review
- Physical activity increases the resistin concentration in hemodialyzed patients without metabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimResistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic inflammation and ischemic heart disease. We studied the relationship of serum concentration of resistin with HDL cholesterol, a known biomarker of PA, and with different measures of PA, in a large sample of the general adult population in the Canary Islands.
methodsCross-sectional study of 6636 adults recruited randomly. We analyzed the correlation of resistin and HDL cholesterol with PA (as metabolic equivalent level [MET]), and fitted the results with linear and logistic regression models using adjustment for age, alcohol consumption and smoking.
resultsMean resistin level was higher in women (p<0.001), correlated inversely with age, HDL cholesterol (p<0.001) and alcohol consumption (p<0.001 in men), and correlated directly with smoking (p<0.001). Resistin correlated inversely with the duration of leisure time PA (p<0.001), leisure time MET (p<0.001) and moderate leisure time PA (p<0.001), with some differences between sexes. Men (OR = 0.78 [0.61-0.99; p<0.05]) and women (OR = 0.75 [0.61-0.92; p<0.01]) in the upper quintile of leisure time PA had a lower risk of elevated resistin. In contrast, a high degree of sedentarism was associated with an increased risk elevated resistin in women (OR = 1.24 [1.04-1.47; p<0.05] and in men (OR = 1.40 [1.01-1.82; p<0.05]).
conclusionsIn our sample of the general population, resistin was inversely associated with measures and levels of PA and HDL cholesterol. The association of resistin with PA was stronger than the association of HDL cholesterol with PA, making resistin a potentially useful biomarker of PA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.