SynthesisPloS one2017
Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis.Journal of diabetes investigation · 2021Pooled it
- Can glyburide be advocated over subcutaneous insulin for perinatal outcomes of women with gestational diabetes? A systematic review and meta-analysis.Archives of gynecology and obstetrics · 2020Pooled it
- Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.Journal of diabetes research · 2019Pooled it
- Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk.PloS one · 2020Trial
- Trial
- 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- A Personalized Dosing Strategy Optimization for Diabetes Management: Applications to Gestational Diabetes Mellitus.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Risk of hypoglycemia by anthropometric measurements in neonates of mothers with diabetes.European journal of pediatrics · 2022Article
- Maternal diabetes negatively impacts fetal health.Open biology · 2022Review
- Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes.American journal of perinatology · 2022Article
- Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis.BMC endocrine disorders · 2021Article
- The effects of insulin therapy on maternal blood pressure and weight in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2021Article
- Long-term follow-up of children with in utero exposure to sulfonylurea medications.Obesity science & practice · 2021Article
- Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth.The Journal of clinical endocrinology and metabolism · 2021Article
- Diabetes in French Guiana, adapting national standards of therapeutic education and care to the amazonian challenge.World journal of diabetes · 2021Review
- Iranian Endocrine Society Guidelines for Screening, Diagnosis, and Management of Gestational Diabetes Mellitus.International journal of endocrinology and metabolism · 2021Review
- Article
- The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.Current diabetes reports · 2019Review
- Gestational Diabetes Mellitus.Endocrinology and metabolism clinics of North America · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this meta-analysis was to determine the efficacy and safety of glyburide as a treatment for gestational diabetes mellitus (GDM) compared to insulin.
methodsA meta-analysis was conducted to compare the management of gestational diabetes with glyburide and insulin. Studies fulfilling all of the following inclusion criteria were included in this meta-analysis: subjects were women with gestational diabetes requiring drug treatment; the comparison treatment included glyburide vs insulin; one or more outcomes (maternal or neonatal) should be provided in the individual study; the study design should be a randomized control trial. Exclusion criteria: non-RCT studies; non-human data. PubMed, Embase and CENTRAL databases were searched from inception until 10 October 2016.
resultsTen randomized control trials involving 1194 participants met the inclusion criteria and were included. 13 primary outcomes (6 maternal, 7 neonatal) and 26 secondary outcomes (9 maternal, 17 neonatal) were detected and analyzed in this study. Glyburide significantly increased the risk of any neonatal hypoglycemia [risk ratio (RR), 1.89; 95% confidence interval (95%CI), 1.26 to 2.82; p = 0.002]. Sensitivity analysis confirmed robustness of this result [RR, 2.29; 95%CI, 1.49 to 3.54; p = 0.0002]. No differences were observed between the two groups with respect to birth weights [mean difference (MD), 79; 95%CI, -64 to 221.99; p = 0.28] and the risk of macrosomia [RR, 1.69; 95%CI, 0.57 to 5.08; p = 0.35].
conclusionFor women with gestational diabetes, no differences in maternal short term outcomes were observed in those treated with glyburide or insulin. However, the incidence of neonatal hypoglycemia was higher in the glyburide group compared to the insulin group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.