ArticlePloS one2017
A Spirochaete is suggested as the causative agent of Akoya oyster disease by metagenomic analysis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hemolymph microbiota and host immunity of crustaceans and mollusks.The ISME journal · 2025Review
- A novel birnavirus identified as the causative agent of summer atrophy of pearl oyster (PeerJ · 2024Article
- Bivalve microbiomes are shaped by host species, size, parasite infection, and environment.PeerJ · 2024Article
- Article
- A high-quality, haplotype-phased genome reconstruction reveals unexpected haplotype diversity in a pearl oyster.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Isolation and characterization of a Vibrio sp. strain MA3 associated with mass mortalities of the pearl oyster Pinctada fucata.Archives of microbiology · 2021Article
- Mass mortality of pearl oyster (PeerJ · 2021Article
- Coupled changes of bacterial community and function in the gut of mud crab (Scylla Paramamosain) in response to Baimang disease.AMB Express · 2019Article
- The comparison of the intensity of human intestinal spirochetes betweenJournal of clinical biochemistry and nutrition · 2019Article
- Microbiome of the Black-Lipped Pearl OysterFrontiers in microbiology · 2019Article
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15 authors.
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Abstract
Mass mortality that is acompanied by reddish browning of the soft tissues has been occurring in cultured pearl oyster, Pinctada fucata martensii. The disease is called Akoya oyster disease (AOD). Although spreading pattern of the disease and transmission experiments suggest that the disease is infectious, the causative agent has not yet been identified. We used shotgun and 16S rRNA-based metagenomic analysis to identify genes that are present specifically in affected oysters. The genes found only in diseased oysters were mostly bacterial origin, suggesting that the causative agent was a bacterial pathogen. This hypothesis was supported by the inhibition of AOD development in naïve oysters injected with the hemolymph of diseased animals followed immediately with penicillin bath-administration. Further analyses of the hemolymph and mantle specifically and universally detected genes of bacteria that belong to phylum Spirochaetes in diseased pearl oysters but not in healthy oysters. By in situ hybridization or immunostaining, a Brachyspira-like bacterium was observed in the smears of hemolymph from affected oysters, but not from healthy oysters. Phylogenetic analysis using 16S rRNA sequences showed that the presumptive causative bacterium was outside of but most closely related to family Brachyspiraceae. We propose 'Candidatus Maribrachyspira akoyae' gen. nov, sp nov., for this bacterium.
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