Evidence map›Paper›PMID 28771358›Full record

ArticleJournal of natural products2017

Stereochemistry of a Second Riolozane and Other Diterpenoids from Jatropha dioica.

Elda M Melchor-Martínez, David A Silva-Mares, Ernesto Torres-López, Noemí Waksman-Minsky, Guido F Pauli, Shao-Nong Chen, Matthias Niemitz, Mariano Sánchez-Castellanos, Alfredo Toscano, Gabriel Cuevas and 1 more

Abstract read
In one paragraph

Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Nephroprotective and Antioxidant Effects ofInternational journal of molecular sciences · 2025
    Article
  3. Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Elda M Melchor-MartínezFacultad de Medicina, Universidad Autónoma de Nuevo León , Avenida Madero y Aguirre Pequeño, Col. Mitras Centro s/n, Monterrey, N.L., C.P. 64460, México.
David A Silva-MaresFacultad de Medicina, Universidad Autónoma de Nuevo León , Avenida Madero y Aguirre Pequeño, Col. Mitras Centro s/n, Monterrey, N.L., C.P. 64460, México.
Ernesto Torres-LópezFacultad de Medicina, Universidad Autónoma de Nuevo León , Avenida Madero y Aguirre Pequeño, Col. Mitras Centro s/n, Monterrey, N.L., C.P. 64460, México.
Noemí Waksman-MinskyFacultad de Medicina, Universidad Autónoma de Nuevo León , Avenida Madero y Aguirre Pequeño, Col. Mitras Centro s/n, Monterrey, N.L., C.P. 64460, México.
Guido F PauliCenter for Natural Product Technologies (CENAPT), Department of Medicinal Chemistry and Pharmacognosy, and Institute for Tuberculosis Research; College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.ORCID 0000-0003-1022-4326
Shao-Nong ChenCenter for Natural Product Technologies (CENAPT), Department of Medicinal Chemistry and Pharmacognosy, and Institute for Tuberculosis Research; College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.ORCID 0000-0003-0748-0863
Matthias NiemitzNMR Solutions Ltd. , Puijonkatu 24B5, 70110 Kuopio, Finland.
Mariano Sánchez-CastellanosInstituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, Ciudad de México, C. P. 04510, México.
Alfredo ToscanoInstituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, Ciudad de México, C. P. 04510, México.
Gabriel CuevasInstituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, Ciudad de México, C. P. 04510, México.
Verónica M Rivas-GalindoFacultad de Medicina, Universidad Autónoma de Nuevo León , Avenida Madero y Aguirre Pequeño, Col. Mitras Centro s/n, Monterrey, N.L., C.P. 64460, México.ORCID 0000-0002-7981-3674
Universidad Autónoma de Nuevo León · MXUniversidad Nacional Autónoma de México · MXUniversity of Illinois Chicago · US

Funding

Center for Natural Product Technologies at UIC (CeNAPT)U41AT008706 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 2015 to 2019
$1.5M
NCCIH NIH HHS U41 AT008706
6 · The paper itself

Abstract

The dichloromethane extract of the roots of Jatropha dioica afforded riolozatrione (1) and a C-6 epimer of riolozatrione, 6-epi-riolozatrione (2), as a new structure and only the second reported riolozane diterpenoid. The two known diterpenoids jatrophatrione (3) and citlalitrione (4) were also isolated and characterized. Both epimers 1 and 2 are genuine plant constituents, with 2 likely being the biosynthesis precursor of 1 due to the tendency for the quantitative transformation of 2 into 1 under base catalysis. The structural characterization and distinction of the stereoisomers utilized

Indexed as

DiterpenesDrug Screening Assays, AntitumorHumansJatrophaMolecular StructurePlant RootsX-Ray DiffractioncitlalitrioneDiterpenesjatrophatrioneriolozatrione

Identifiers

PMID28771358
PMCPMC5714812
OpenAlexW2745045967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.