ReviewChildren (Basel, Switzerland)2017
The Fetus Can Teach Us: Oxygen and the Pulmonary Vasculature.
Review in Children (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Role of fetal pulmonary artery Doppler parameters for predicting neonatal respiratory distress syndrome: A systematic review and meta-analysis of diagnostic accuracy.European journal of obstetrics & gynecology and reproductive biology: X · 2026Review
- Extracorporeal Life Support in ARDS: Lessons from Maternal-Fetal Physiology.Advances in respiratory medicine · 2026Article
- Comparison of indomethacin and nifedipine regarding ductus arteriosus Doppler findings after laser therapy for monochorionic diamniotic twin-to-twin transfusion syndrome: A retrospective cohort study.International journal of reproductive biomedicine · 2026Article
- Impact of varying range of maternal oxygenation targets on fetal oxygenation and fetoplacental circulation in an ovine model of pregnancy.Pediatric research · 2026Article
- The Destructive Cycle in Bronchopulmonary Dysplasia: The Rationale for Systems Pharmacology Therapeutics.Antioxidants (Basel, Switzerland) · 2025Review
- MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Oxygen saturation targets in neonatal care: A narrative review.Early human development · 2024Review
- Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping.Pediatric research · 2024Review
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.Clinics in perinatology · 2024Review
- Early Pulmonary Hypertension in Preterm Infants.Clinics in perinatology · 2024Review
- Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study.European journal of translational myology · 2024Article
- Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation-a literature review.Pediatric medicine (Hong Kong, China) · 2023Article
- Prenatal Hypoxia Affects Foetal Cardiovascular Regulatory Mechanisms in a Sex- and Circadian-Dependent Manner: A Review.International journal of molecular sciences · 2022Review
- Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta.Frontiers in physiology · 2022Article
- Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Cardiac Output and Its Distribution to Different Organs during Development.Clinical pharmacokinetics · 2021Review
- Inhaled Nitric Oxide at Birth Reduces Pulmonary Vascular Resistance and Improves Oxygenation in Preterm Lambs.Children (Basel, Switzerland) · 2021Article
- Neonatal and Postneonatal Pulmonary Hypertension.Children (Basel, Switzerland) · 2021Article
- Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia.European journal of clinical pharmacology · 2020Article
- Oxygen Supplementation During Preterm Stabilization and the Relevance of the First 5 min After Birth.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neonates suffering from pulmonary hypertension of the newborn (PPHN) continue to represent an important proportion of patients requiring intensive neonatal care, and have an increased risk of morbidity and mortality. The human fetus has evolved to maintain a high pulmonary vascular resistance (PVR) in utero to allow the majority of the fetal circulation to bypass the lungs, which do not participate in gas exchange, towards the low resistance placenta. At birth, oxygen plays a major role in decreasing PVR to enhance pulmonary blood flow and establish the lungs as the organ of gas exchange. The failure of PVR to fall following birth results in PPHN, and oxygen remains the mainstay therapeutic intervention in the management of PPHN. Knowledge gaps on what constitutes the optimal oxygenation target leads to a wide variation in practices, and often leads to excessive oxygen use. Owing to the risk of oxygen toxicity, avoiding hyperoxemia is as important as avoiding hypoxemia in the management of PPHN. Current evidence supports maintaining arterial oxygen tension in the range of 50-80 mm Hg, and oxygen saturation between 90-97% in term infants with hypoxemic respiratory failure. Clinical studies evaluating the optimal oxygenation in the treatment of PPHN will be enthusiastically awaited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.