Evidence map›Paper›PMID 28771188›Full record

ArticleMolecules (Basel, Switzerland)2017

Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus.

Minqian Wang, Jenni Firrman, Liqing Zhang, Gustavo Arango-Argoty, Peggy Tomasula, LinShu Liu, Weidong Xiao, Kit Yam

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. High Flavonoid Content inPharmaceutical nanotechnology · 2026
    Article
  2. Review
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  4. International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minqian WangDairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 E Mermaid Lane, Wyndmoor, PA 19038, USA. Minqian.Wang@ars.usda.gov.
Jenni FirrmanDairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 E Mermaid Lane, Wyndmoor, PA 19038, USA. Jenni.Firrman@ars.usda.gov.
Liqing ZhangDepartment of Computer Science, Virginia Tech, 114 MCB Hall, Blacksburg, VA 24060, USA. lqzhang@cs.vt.edu.
Gustavo Arango-ArgotyDepartment of Computer Science, Virginia Tech, 114 MCB Hall, Blacksburg, VA 24060, USA. gustavo1@vt.edu.
Peggy TomasulaDairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 E Mermaid Lane, Wyndmoor, PA 19038, USA. peggy.tomasula@ars.usda.gov.
LinShu LiuDairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 E Mermaid Lane, Wyndmoor, PA 19038, USA. linshu.liu@ars.usda.gov.
Weidong XiaoDepartment of Microbiology and Immunology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA. WXiao@temple.edu.
Kit YamDepartment of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. kyam@sebs.rutgers.edu.

Funding

Molecular Biology of Recombinant AAV GenomesR01HL080789 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2006 to 2014
$3.1M
Novel adeno-associated virus vector production system developmentR01HL114152 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2012 to 2016
$2.2M
Development of highly efficient factor VIII mini-gene therapyR01HL130871 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL080789NHLBI NIH HHS R01 HL114152
6 · The paper itself

Abstract

Apigenin is a major dietary flavonoid with many bioactivities, widely distributed in plants. Apigenin reaches the colon region intact and interacts there with the human gut microbiota, however there is little research on how apigenin affects the gut bacteria. This study investigated the effect of pure apigenin on human gut bacteria, at both the single strain and community levels. The effect of apigenin on the single gut bacteria strains

Indexed as

ApigeninBacterial ProteinsEnterococcusGastrointestinal MicrobiomeGene Expression Regulation, BacterialApigeninBacterial ProteinsapigeninEnterococcusgut microbiotasingle molecule RNA sequencing

Identifiers

PMID28771188
PMCPMC6152273

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.