ReviewInternational journal of molecular sciences2017
Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Effects of oral health interventions on cognition of people with dementia: a systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Masticatory Dysfunction by Extensive Tooth Loss as a Risk Factor for Cognitive Deficit: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2019Pooled it
- Trial
- Anxiolytic effects of chewing gum during preoperative fasting and patient-centered outcome in female patients undergoing elective gynecologic surgery: randomized controlled study.Scientific reports · 2022Trial
- Masticatory performance in aging populations: A scoping review of research landscapes in Japan, Sweden, and India.The Japanese dental science review · 2026Review
- Putting Pork on the Menu: Consumers' Acceptability of Pork Meals with and Without Naturally Wood-Smoked Bacon.Foods (Basel, Switzerland) · 2026Article
- Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications.International journal of oral science · 2026Review
- Neural Control of Mastication: Ion-Channel Mechanisms in the Brainstem Central Pattern Generator.Brain sciences · 2026Review
- Hypoglossal Nerve Transection Induces Anxiety- and Depression-like Behaviors with HPA Axis Dysregulation in Rats.Bioengineering (Basel, Switzerland) · 2026Article
- The DentoNeural Axis: A Piezo channel-mediated mechanosensory pathway linking tooth loss to cognitive decline.Aging brain · 2026Article
- Using minimally invasive aesthetic repair, dental fluorosis vertical distance of occlusion restoration: A case report.Medicine · 2025Article
- Chewing modulates theta oscillation and functional connectivity of the frontocentral cortex in attention and working memory.Scientific reports · 2025Article
- Article
- Association Between Gum Chewing and Temporomandibular Disorders.Journal of clinical medicine · 2025Article
- The Neural Correlates of Chewing Gum-A Neuroimaging Review of Its Effects on Brain Activity.Brain sciences · 2025Review
- Association between oral health and physio-cognitive decline syndrome of older adults in China and its sex differences: a cross-sectional study.BMC geriatrics · 2025Article
- Functional significance and welfare implications of chewing in dogs (Frontiers in veterinary science · 2025Review
- Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia.Journal of clinical periodontology · 2025Article
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mastication is mainly involved in food intake and nutrient digestion with the aid of teeth. Mastication is also important for preserving and promoting general health, including hippocampus-dependent cognition. Both animal and human studies indicate that mastication influences hippocampal functions through the end product of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoid (GC). Epidemiologic studies suggest that masticatory dysfunction in aged individuals, such as that resulting from tooth loss and periodontitis, acting as a source of chronic stress, activates the HPA axis, leading to increases in circulating GCs and eventually inducing various physical and psychological diseases, such as cognitive impairment, cardiovascular disorders, and osteoporosis. Recent studies demonstrated that masticatory stimulation or chewing during stressful conditions suppresses the hyperactivity of the HPA axis via GCs and GC receptors within the hippocampus, and ameliorates chronic stress-induced hippocampus-dependent cognitive deficits. Here, we provide a comprehensive overview of current research regarding the association between mastication, the hippocampus, and HPA axis activity. We also discuss several potential molecular mechanisms involved in the interactions between mastication, hippocampal function, and HPA axis activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.