ArticleACS applied materials & interfaces2017
Real-Time Monitoring of Insulin Using a Graphene Field-Effect Transistor Aptameric Nanosensor.
Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 137 citations in OpenAlex.
- Nucleic Acid-Based Field-Effect Transistor Biosensors.Biosensors · 2026Review
- Advances in the Application of Graphene and Its Derivatives in Drug Delivery Systems.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Recent Advances in Xenes Based FET for Biosensing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advanced Materials for Biological Field-Effect Transistors (Bio-FETs) in Precision Healthcare and Biosensing.Advanced healthcare materials · 2025Review
- A Planar-Gate Graphene Field-Effect Transistor Integrated Portable Platform for Rapid Detection of Colon Cancer-Derived Exosomes.Biosensors · 2025Article
- Real-Time Monitoring in Biomanufacturing with Graphene Field-Effect Transistor Sensors: Detection of pH, Glucose, and Antibodies.GEN biotechnology · 2024Article
- Modular Fabrication of Microfluidic Graphene FET for Nucleic Acids Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- 2D Materials in Advanced Electronic Biosensors for Point-of-Care Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Aptameric Metal-Organic Framework Nanobiosensor.ACS applied nano materials · 2024Article
- The Minimally-Invasive Oral Glucose Minimal Model: Estimation of Gastric Retention, Glucose Rate of Appearance, and Insulin Sensitivity From Type 1 Diabetes Data Collected in Real-Life Conditions.IEEE transactions on bio-medical engineering · 2024Article
- Rapid and Easy Detection of Microcystin-LR Using a Bioactivated Multi-Walled Carbon Nanotube-Based Field-Effect Transistor Sensor.Biosensors · 2024Article
- Challenges for Field-Effect-Transistor-Based Graphene Biosensors.Materials (Basel, Switzerland) · 2024Review
- Field effect transistor based wearable biosensors for healthcare monitoring.Journal of nanobiotechnology · 2023Review
- Review
- Clinical Evaluation of a Novel Insulin Immunosensor.Journal of diabetes science and technology · 2023Article
- Aptamer-functionalized field-effect transistor biosensors for disease diagnosis and environmental monitoring.Exploration (Beijing, China) · 2023Review
- A versatile bioelectronic interface programmed for hormone sensing.Nature communications · 2023Article
- Epidermal Wearable Biosensors for Monitoring Biomarkers of Chronic Disease in Sweat.Biosensors · 2023Review
- Chemical Sensor Nanotechnology in Pharmaceutical Drug Research.Nanomaterials (Basel, Switzerland) · 2022Review
- Biofunctionalization of Graphene-Based FET Sensors through Heterobifunctional Nanoscaffolds: Technology Validation toward Rapid COVID-19 Diagnostics and Monitoring.Advanced materials interfaces · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
This paper presents an approach to the real-time, label-free, specific, and sensitive monitoring of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a field-effect transistor, whose graphene-based conducting channel is functionalized with a guanine-rich IGA3 aptamer. The negatively charged aptamer folds into a compact and stable antiparallel or parallel G-quadruplex conformation upon binding with insulin, resulting in a change in the carrier density, and hence the electrical conductance, of the graphene. The change in the electrical conductance is then measured to enable the real-time monitoring of insulin levels. Testing has shown that the nanosensor offers an estimated limit of detection down to 35 pM and is functional in Krebs-Ringer bicarbonate buffer, a standard pancreatic islet perfusion medium. These results demonstrate the potential utility of this approach in label-free monitoring of insulin and in timely prediction of accurate insulin dosage in clinical diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.