Evidence map›Paper›PMID 28770934›Full record

ArticleChemical communications (Cambridge, England)2017

Albumin removal from human serum using surface nanopockets on silica-coated magnetic nanoparticles.

Snehasis Bhakta, Chandra K Dixit, Itti Bist, John Macharia, Min Shen, Karteek Kadimisetty, Junkai He, Biswanath Dutta, Steven L Suib, James F Rusling

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 30 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Snehasis BhaktaDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269-3060, USA. Steven.suib@uconn.edu James.rusling@uconn.edu.
Chandra K Dixit
Itti Bist
John Macharia
Min Shen
Karteek Kadimisetty
Junkai He
Biswanath Dutta
Steven L Suib
James F Rusling
University of Connecticut · US

Funding

Protein Biomarker Arrays for Personalized Treatment of Prostate CancerR01EB016707 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2014 to 2017
$1.4M
NIBIB NIH HHS R01 EB016707
6 · The paper itself

Abstract

Selective removal of albumin from human serum is an essential step prior to proteomic analyses, especially when using mass spectrometry. Here we report stable synthetic nanopockets on magnetic nanoparticle surfaces that bind to human serum albumin (HSA) with high affinity and specificity. The nanopockets are created by templating HSA on 200 nm silica-coated paramagnetic nanoparticles using polymer layers made using 4 organo-silane monomers. These monomers have amino acid-like side chains providing hydrophobic, hydrophilic and H-bonding interactions that closely mimic features of binding sites on antibodies. The binding capacity of the material was 21 mg HSA g

Indexed as

HumansMagnetite NanoparticlesParticle SizeSerum AlbuminSilicon DioxideSurface PropertiesMagnetite NanoparticlesSerum AlbuminSilicon Dioxide

Identifiers

PMID28770934
PMCPMC5586046
OpenAlexW2742010907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.