Evidence map›Paper›PMID 28770829›Full record

ArticleActa pharmacologica Sinica2018

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells.

Ya-Juan Zhang, Hua-Qing Zheng, Bao-Yi Chen, Lu Sun, Ming-Ming Ma, Guan-Lei Wang, Yong-Yuan Guan

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Hypotonicity-Induced WNK1 Phosphorylation Prevents HBasic & clinical pharmacology & toxicology · 2026
    Article
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  12. Review
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  17. WNK pathways in cancer signaling networks.Cell communication and signaling : CCS · 2018
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ya-Juan ZhangDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Hua-Qing ZhengDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Bao-Yi ChenDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Lu SunDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Ming-Ming MaDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Guan-Lei WangDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Yong-Yuan GuanDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypotonic challenge evoked vascular cell proliferation through activation of volume-regulated Cl

Indexed as

Cell ProliferationAnimalsCell LineChloridesCyclin D1CyclinsG1 Phase Cell Cycle CheckpointsHypotonic SolutionsMuscle, Smooth, VascularMutationPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktRatsWNK Lysine-Deficient Protein Kinase 1Ccnd1 protein, ratChloridesCyclin D1cyclin E1, ratCyclinsHypotonic SolutionsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktWnk1 protein, ratWNK Lysine-Deficient Protein Kinase 1

Identifiers

PMID28770829
PMCPMC5758668
OpenAlexW2742241671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.