ReviewThe journal of spinal cord medicine2018
Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review.
Review in The journal of spinal cord medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01652040 (Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Low testosterone is associated with steatosis in the male population with spinal cord injury.Archives of endocrinology and metabolism · 2025Article
- Neurogenic Aging After Spinal Cord Injury: Highlighting the Unique Characteristics of Aging After Spinal Cord Injury.Journal of clinical medicine · 2024Review
- Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury-a randomized, double-blind, and placebo-controlled pilot study.Frontiers in neurology · 2024Article
- A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities.Military Medical Research · 2023Review
- Denervation impacts muscle quality and knee bone mineral density after spinal cord injury.Spinal cord · 2023Article
- Role of exercise on visceral adiposity after spinal cord injury: a cardiometabolic risk factor.European journal of applied physiology · 2021Review
- Low-dose testosterone replacement therapy and electrically evoked resistance training enhance muscle quality after spinal cord injury.Neural regeneration research · 2021Article
- The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts.Sexual medicine · 2020Review
- Endocrine Therapy for the Functional Recovery of Spinal Cord Injury.Frontiers in neuroscience · 2020Review
- Dietary manipulation and testosterone replacement therapy may explain changes in body composition after spinal cord injury: A retrospective case report.World journal of clinical cases · 2019Article
- Serum testosterone levels may influence body composition and cardiometabolic health in men with spinal cord injury.Spinal cord · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood, erythropoiesis, cognition and quality of life. Hypogonadism can occur due to several underlying pathologies during aging and in men with physical disabilities, such as spinal cord injury (SCI). This condition is often under diagnosed and as a result, symptoms undertreated. Methods In this mini-review, we propose that testosterone replacement therapy (TRT) may be a viable strategy to improve lean body mass (LBM) and fat mass (FM) in men with SCI. Evidence Synthesis Supplementing the limited data from SCI cohorts with consistent findings from studies in non-disabled aging men, we present evidence that, relative to placebo, transdermal TRT can increase LBM and reduce FM over 3-36 months. The impact of TRT on bone mineral density and metabolism is also discussed, with particular relevance for persons with SCI. Moreover, the risks of TRT remain controversial and pertinent safety considerations related to transdermal administration are outlined. Conclusion Further research is necessary to help develop clinical guidelines for the specific dose and duration of TRT in persons with SCI. Therefore, we call for more high-quality randomized controlled trials to examine the efficacy and safety of TRT in this population, which experiences an increased risk of cardiometabolic diseases as a result of deleterious body composition changes after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.