ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2017
The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Magnetization transfer MRI (MT-MRI) detects white matter damage beyond the primary site of compression in degenerative cervical myelopathy using a novel semi-automated analysis.Computers in biology and medicine · 2025Article
- Deep medullary veins: a promising neuroimaging marker for neurodegeneration in multiple sclerosis.Quantitative imaging in medicine and surgery · 2025Article
- Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2024Review
- Myelin water quantification in multiple sclerosis using short repetition time adiabatic inversion recovery prepared-fast spin echo (STAIR-FSE) imaging.Quantitative imaging in medicine and surgery · 2024Article
- A Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments.Biomedicines · 2023Review
- The Role of fMRI in Drug Development: An Update.Advances in neurobiology · 2023Article
- Neural diffusion tensor imaging metrics correlate with clinical measures in people with relapsing-remitting MS.The neuroradiology journal · 2022Article
- Escalation vs. Early Intense Therapy in Multiple Sclerosis.Journal of personalized medicine · 2022Review
- Omics-Driven Biotechnology for Industrial Applications.Frontiers in bioengineering and biotechnology · 2021Review
- Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual-vendor reproducibility and repeatability study.Human brain mapping · 2020Article
- Vitamin D and MRI measures in progressive multiple sclerosis.Multiple sclerosis and related disorders · 2019Article
- Diagnosis and Management of Progressive Multiple Sclerosis.Biomedicines · 2019Review
- Review
- The vast potential and bright future of neuroimaging.The British journal of radiology · 2018Review
- Article
- Why monkeys do not get multiple sclerosis (spontaneously): An evolutionary approach.Evolution, medicine, and public health · 2018Review
- Multiple Sclerosis: Unprecedented Progress But Significant Challenges Ahead.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Article
- Remyelinating Pharmacotherapies in Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Magnetic resonance imaging has been crucial in the development of anti-inflammatory disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and restorative therapies. This is especially true of therapies targeting progressive forms of the disease where neurodegeneration is a prominent feature. Imaging techniques of the brain and spinal cord have rapidly evolved in the last decade to permit in vivo characterization of tissue microstructural changes, connectivity, metabolic changes, neuronal loss, glial activity, and demyelination. Advanced magnetic resonance imaging techniques hold significant promise for accelerating the development of different treatment modalities targeting a variety of pathways in MS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.