Evidence map›Paper›PMID 28770447›Full record

ArticleJournal of endocrinological investigation2018

The effect of primary hyperparathyroidism on pancreatic exocrine function.

P Sisman, M Avci, A Akkurt, A B Sahin, O O Gul, C Ersoy, E Erturk

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Primary hyperparathyroidism and pancreatitis.Journal of endocrinological investigation · 2020
    Article
  2. PHPT with Pancreatitis: Atypical Presentation of PHPT.Indian journal of endocrinology and metabolism
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

P SismanEndocrinology and Metabolism Clinic, Harakani State Hospital, Kars, Turkey. pinar.sisman@hotmail.com.
M AvciDepartment Of Internal Medicine, Uludag University Medical School, Bursa, Turkey.
A AkkurtEndocrinology and Metabolism Clinic, Muradiye State Hospital, Bursa, Turkey.
A B SahinDepartment Of Internal Medicine, Uludag University Medical School, Bursa, Turkey.
O O GulDepartment of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey.
C ErsoyDepartment of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey.
E ErturkDepartment of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey.
Bursa Uludağ Üni̇versi̇tesi̇ · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElastase-1 is a proteolytic enzyme secreted by pancreatic acinar cells, and measurements of the concentration this enzyme are used to evaluate pancreatic exocrine function. We aimed to determine whether pancreatic exocrine function declines due to chronic hypercalcemia by measuring fecal elastase levels.

methods75 patients with primary hyperparathyroidism (18 men and 47 women) and 30 healthy subjects (11 men and 19 women) participated in this study. Renal function tests, lipid parameters, bone mineral density, and serum calcium, phosphorus, vitamin D, parathormone, glucose, and thyroid stimulating hormone levels as well as fecal elastase concentrations, were determined in these patients and controls.

resultsThe mean fecal elastase level was 335.3 ± 181.4 μg/g in the PHPT group and 317.4 ± 157.3 μg/g in the control group. There was no significant difference in fecal elastase levels between the two groups (p = 0.5).

conclusionsChronic hypercalcemia in primary hyperparathyroidism did not decrease the fecal elastase level, which is an indirect indicator of chronic pancreatitis; therefore, chronic hypercalcemia in PHPT may not cause chronic pancreatitis.

Indexed as

AdultAgedAged, 80 and overBiomarkersCase-Control StudiesExocrine Pancreatic InsufficiencyFecesFemaleFollow-Up StudiesHumansHypercalcemiaHyperparathyroidism, PrimaryMaleMiddle AgedPancreatic ElastasePancreatitis, ChronicBiomarkersPancreatic ElastaseFecal elastasePancreatic exocrine functionsPrimary hyperparathyroidism

Identifiers

PMID28770447
OpenAlexW2741316530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.