Evidence map›Paper›PMID 28770390›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2017

Genome-wide significant, replicated and functional risk variants for Alzheimer's disease.

Xiaoyun Guo, Wenying Qiu, Rolando Garcia-Milian, Xiandong Lin, Yong Zhang, Yuping Cao, Yunlong Tan, Zhiren Wang, Jing Shi, Jijun Wang and 14 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Quantitative Trait Module-Based Genetic Analysis of Alzheimer's Disease.International journal of molecular sciences · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 14 institutions in 2 countries.

Xiaoyun GuoShanghai Mental Health Center, Shanghai, 200030, China.
Wenying QiuDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Rolando Garcia-MilianCurriculum and Research Support Department, Cushing/Whitney Medical Library, Yale University School of Medicine, New Haven, CT, 06510, USA.
Xiandong LinDepartment of Pathology, Fujian Provincial Cancer Hospital, The Teaching Hospital of Fujian Medical University, Fuzhou, 350014, Fujian, China.
Yong ZhangTianjin Mental Health Center, Tianjin, 300222, China.
Yuping CaoDepartment of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, 410012, China.
Yunlong TanBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, 100096, China.
Zhiren WangBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, 100096, China.
Jing ShiBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, 100096, China.
Jijun WangShanghai Mental Health Center, Shanghai, 200030, China.
Dengtang LiuShanghai Mental Health Center, Shanghai, 200030, China.
Lisheng SongShanghai Mental Health Center, Shanghai, 200030, China.
Yifeng XuShanghai Mental Health Center, Shanghai, 200030, China.
Xiaoping WangDepartment of Neurology, Shanghai Tongren Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Na LiuNanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, China.
Tao SunHuashan Hospital, Fudan University School of Medicine, Shanghai, 200040, China.
Jianming ZhengHuashan Hospital, Fudan University School of Medicine, Shanghai, 200040, China.
Justine LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA.
Huihao ZhangThe First Affiliated Hospital, Fujian Medical University, Fuzhou, 350001, China.
Jianying XuZhuhai Municipal Maternal and Children's Health Hospital, Zhuhai, 519000, Guangdong, China.
Longli KangKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of Tibet Autonomous Region, Xizang Minzu University School of Medicine, Xiangyang, 712082, Shaanxi, China.
Chao MaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Kesheng WangDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, 37614, USA.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA. Xingguang.Luo@yale.edu.
Beijing HuiLongGuan Hospital · CNShanghai Mental Health Center · CNYale University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNHuashan Hospital · CNCentral South University · CNEast Tennessee State University · USFirst Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CNNanjing Brain Hospital · CNTianjin Anding Hospital · CNTongren Hospital · CNWeihai Maternal and Child Health Hospital · CNXizang Minzu University · CN

Funding

Deep Sequencing of CNR1 Gene Network in Substance DependenceK01DA029643 · NIDA · YALE UNIVERSITY · PI ZUO, LINGJUN · 2010 to 2014
$909k
Sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependenceR21AA020319 · NIAAA · YALE UNIVERSITY · PI ZUO, LINGJUN · 2011 to 2012
$344k
Post-GWAS transcriptome-wide LncRNA expression profiling in alcohol dependenceR21AA023237 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2015 to 2016
$344k
Deep sequencing of genes in ethanol-metabolism pathway in alcoholismR21AA021380 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2014 to 2015
$339k
NIAAA NIH HHS R21 AA020319NIAAA NIH HHS R21 AA021380NIAAA NIH HHS R21 AA023237NIDA NIH HHS K01 DA029643
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have reported numerous associations between risk variants and Alzheimer's disease (AD). However, these associations do not necessarily indicate a causal relationship. If the risk variants can be demonstrated to be biologically functional, the possibility of a causal relationship would be increased. In this article, we reviewed all of the published GWASs to extract the genome-wide significant (p < 5×10

Indexed as

Genetic Predisposition to DiseaseAlzheimer DiseaseApolipoproteins EGene ExpressionGenome-Wide Association StudyHumansPolymorphism, Single NucleotideProteinsRisk FactorsApolipoproteins EProteinsAlzheimer’s diseaseAPOEGene expressionGenome-wide significantGWASReplicatedRisk variant

Identifiers

PMID28770390
PMCPMC5654670
OpenAlexW2741368631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.