ArticleCardiovascular and interventional radiology2018
Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma.
Article in Cardiovascular and interventional radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Quantitative analysis of lung microwave ablation zone volume and shape.European radiology experimental · 2026Article
- Automated Deformable Registration and Three-dimensional Margin Assessment for Predicting Local Recurrence after Lung Thermal Ablation.Radiology. Imaging cancer · 2026Article
- Robotic-assisted bronchoscopy for histopathologic subtyping of primary lung adenocarcinoma.Lung cancer (Amsterdam, Netherlands) · 2025Article
- Leveraging deep learning for more accurate prediction of lung microwave ablation zones.European radiology · 2024Article
- Pre-operative lung ablation prediction using deep learning.European radiology · 2024Article
- Use of Computed Tomography-Guided Percutaneous Biopsy of Invasive Non-Mucinous Lung Adenocarcinoma to Predict the Degree of Histological Differentiation.Clinical Medicine Insights. Oncology · 2022Article
- Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification.Korean journal of radiology · 2021Article
- Radiogenomics in Interventional Oncology.Current oncology reports · 2021Review
- Prognostic significance of micropapillary and solid patterns in stage IA lung adenocarcinoma.American journal of translational research · 2021Article
- Computerized tomography-Guided Microwave Ablation of Patients with Stage I Non-small Cell Lung Cancers: A Single-Institution Retrospective Study.Journal of clinical imaging science · 2021Article
- Article
- CT-Guided Core Biopsy for Peripheral Sub-solid Pulmonary Nodules to Predict Predominant Histological and Aggressive Subtypes of Lung Adenocarcinoma.Annals of surgical oncology · 2020Article
- A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients.World journal of surgical oncology · 2020Article
- Microwave Ablation in Primary Lung Malignancies.Seminars in interventional radiology · 2019Review
- Utility of Core Biopsy Specimen to Identify Histologic Subtype and Predict Outcome for Lung Adenocarcinoma.The Annals of thoracic surgery · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundTo investigate whether histologic subtyping from biopsies can predict local recurrence after thermal ablation for lung adenocarcinoma.
methodsPatients treated with CT-guided thermal ablation for lung adenocarcinoma that had pre-ablation needle biopsy with analysis of histologic components were identified. Age, gender, smoking status, treatment indication (primary stage 1 tumor versus salvage), histologic subtype, ground-glass radiographic appearance, tumor size, ablation modality, and ablation margin were evaluated in relation to time to local recurrence (TTLR). Cumulative incidence of recurrence (CIR) was calculated using competing risks analysis and compared across groups using Fine and Grey method with clustering. Multivariate analysis was conducted with stepwise regression.
resultsThere were 53 patients with 57 tumors diagnosed as adenocarcinoma on pre-ablation biopsy and with histologic subtype analysis. Of these, 19% (11) had micropapillary components, 14% (8) had solid components, and 26% (15) had micropapillary and/or solid components. In the univariate analysis, solid (subdistribution hazard ratio [SHR] = 4.04, p = 0.0051, 95% confidence interval [CI] = 1.52-10.7), micropapillary (SHR = 3.36, p = 0.01, CI = 1.33-8.47), and micropapillary and/or solid components (SHR = 5.85, p = 0.00038, CI = 2.21-15.5) were significantly correlated with shorter TTLR. On multivariate analysis, the presence of micropapillary and/or solid component (SHR = 11.4, p = 0.00021, CI: 3.14-41.3) was the only independent predictor of TTLR. The 1-, 2-, and 3-year CIR in patients with micropapillary and/or solid components was 33, 49, and 66% compared to 5, 14, and 18% in patients with no micropapillary or solid components on biopsy specimens.
conclusionMicropapillary and/or solid histologic components identified in pre-ablation biopsy are associated with shorter TTLR after thermal ablation of lung adenocarcinoma.
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