ArticleChem2017
Nanoparticle-Based Receptors Mimic Protein-Ligand Recognition.
Article in Chem, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Review
- A Scoring Function for Monolayer-Protected Gold Nanoparticles Capable of Recognizing Small Organic Molecules in Solution.Journal of chemical theory and computation · 2025Article
- Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review.Current medicinal chemistry · 2025Review
- Molecular Mechanisms Underlying Detection Sensitivity in Nanoparticle-Assisted NMR Chemosensing.The journal of physical chemistry letters · 2023Article
- NanoModeler CG: A Tool for Modeling and Engineering Functional Nanoparticles at a Coarse-Grained Resolution.Journal of chemical theory and computation · 2023Article
- Spotting Local Environments in Self-Assembled Monolayer-Protected Gold Nanoparticles.ACS nano · 2022Article
- Fluorescent Sensing of Glutathione and Related Bio-Applications.Biosensors · 2022Review
- Article
- Engineering the Aggregation of Dyes on Ligand-Shell Protected Gold Nanoparticles to Promote Plexcitons Formation.Nanomaterials (Basel, Switzerland) · 2022Article
- Role of Ionic Strength in the Formation of Stable Supramolecular Nanoparticle-Protein Conjugates for Biosensing.International journal of molecular sciences · 2022Article
- On the Metal-Aided Catalytic Mechanism for Phosphodiester Bond Cleavage Performed by Nanozymes.ACS catalysis · 2021Article
- Association Mechanism of Peptide-Coated Metal Nanoparticles with Model Membranes: A Coarse-Grained Study.Journal of chemical theory and computation · 2021Article
- Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers.Communications chemistry · 2021Article
- Molecular Recognition by Gold Nanoparticle-Based Receptors as Defined through Surface Morphology and Pockets Fingerprint.The journal of physical chemistry letters · 2021Article
- The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Molecular Dynamics Simulations of a Catalytic Multivalent Peptide-Nanoparticle Complex.International journal of molecular sciences · 2021Article
- A Gold Nanoparticle Nanonuclease Relying on a Zn(II) Mononuclear Complex.Angewandte Chemie (International ed. in English) · 2021Article
- Dispersion state phase diagram of citrate-coated metallic nanoparticles in saline solutions.Nature communications · 2020Article
- Dendrimers as Modulators of Brain Cells.Molecules (Basel, Switzerland) · 2020Review
- Catalytically Active Peptide-Gold Nanoparticle Conjugates: Prospecting for Artificial Enzymes.Angewandte Chemie (International ed. in English) · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The self-assembly of a monolayer of ligands on the surface of noble-metal nanoparticles dictates the fundamental nanoparticle's behavior and its functionality. In this combined computational-experimental study, we analyze the structure, organization, and dynamics of functionalized coating thiols in monolayer-protected gold nanoparticles (AuNPs). We explain how functionalized coating thiols self-organize through a delicate and somehow counterintuitive balance of interactions within the monolayer itself and with the solvent. We further describe how the nature and plasticity of these interactions modulate nanoparticle-based chemosensing. Importantly, we found that self-organization of coating thiols can induce the formation of binding pockets in AuNPs. These transient cavities can accommodate small molecules, mimicking protein-ligand recognition, which could explain the selectivity and sensitivity observed for different organic analytes in NMR chemosensing experiments. Thus, our findings advocate for the rational design of tailored coating groups to form specific recognition binding sites on monolayer-protected AuNPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.