ReviewFrontiers in medicine2017
Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel.
Review in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Advances in diagnostic techniques for eosinophilic esophagitis: a systematic review of emerging noninvasive methods.European journal of medical research · 2025Pooled it
- Article
- Article
- Eosinophilic esophagitis in the "atopic march": dupilumab as an "umbrella" strategy for multiple coexisting atopic diseases.Frontiers in medicine · 2024Review
- Diagnostic merits of the Eosinophilic Esophagitis Diagnostic Panel from a single esophageal biopsy.The Journal of allergy and clinical immunology · 2022Article
- Non-invasive biomarkers of eosinophilic esophagitis.Acta bio-medica : Atenei Parmensis · 2021Review
- Eosinophilic Esophagitis: A Review.JAMA · 2021Review
- Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort.The Journal of allergy and clinical immunology · 2020Article
- Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications.Expert review of clinical immunology · 2019Review
- Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.The lancet. Gastroenterology & hepatology · 2018Observational
- The Role of Proton Pump Inhibitors in the Management of Pediatric Eosinophilic Esophagitis.Frontiers in pediatrics · 2018Review
- Clinical and Biological Markers in Hypereosinophilic Syndromes.Frontiers in medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophilic esophagitis (EoE) is a recently recognized upper gastrointestinal allergic disorder characterized by esophageal dysfunction (e.g., dysphagia) and esophageal eosinophilia of ≥15 eosinophils/high-power field in patients who have persistent esophagitis even on proton pump inhibitor (PPI) therapy. The histologic method is the gold standard of EoE diagnosis. However, EoE clinical symptoms do not always correlate with histology, and the histologic method has sensitivity and specificity issues due to the patchiness of EoE and the subjective nature of the method. The "EoE transcriptome" was initially discovered in 2006, which led to the invention of the EoE diagnostic panel (EDP). In addition to providing a definitive EoE diagnosis with high accuracy, the EDP has been useful in elucidating several key elements about the disease including the efficacy of specific drugs such as swallowed glucocorticoids and anti-IL-13 humanized antibody therapy, the relationship between EoE and PPI-responsive esophageal eosinophilia, and predicting the disease course and responsiveness to therapy. The EDP's long-term potential arises from its plasticity to incorporate new genes and uncover novel disease pathogenesis. We expect that the EDP will be increasingly helpful for personalized medicine approaches and improved diagnostics and disease monitoring.
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