Evidence map›Paper›PMID 28770113›Full record

ReviewNeural plasticity2017

Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer's Disease.

Jian-Jiao Chen, Bin Zhao, Jie Zhao, Shao Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Extracellular Vesicles in Tauopathies: Mechanisms and Applications.International journal of molecular sciences · 2026
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  20. Exosomes in schizophrenia: Pathophysiological mechanisms, biomarkers, and therapeutic targets.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jian-Jiao ChenDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian City, Liaoning Province 116044, China.
Bin ZhaoTechnology Centre of Target-Based Nature Products for Prevention and Treatment of Aging-Related Neurodegeneration, Dalian Medical University, Dalian, Liaoning, China.
Jie ZhaoDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian City, Liaoning Province 116044, China.ORCID 0000-0002-1880-2293
Shao LiDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian City, Liaoning Province 116044, China.ORCID 0000-0001-8488-3100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are bilipid layer-enclosed vesicles derived from endosomes and are released from neural cells. They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) that are delivered to neighboring cells and/or are transported to distant sites. miRNAs released from exosomes appear to be associated with multiple neurodegenerative conditions linking to Alzheimer's disease (AD) which is marked by hyperphosphorylated tau proteins and accumulation of A

Indexed as

Alzheimer DiseaseAnimalsBiomarkersEncephalitisEpigenesis, GeneticExosomesGene Transfer TechniquesHumansMicroRNAsBiomarkersMicroRNAs

Identifiers

PMID28770113
PMCPMC5523215

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.