Evidence map›Paper›PMID 28770103›Full record

ArticleThe journal of pathology. Clinical research2017

Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma.

Matthias Christgen, Stephan Bartels, Jana Lisa van Luttikhuizen, Maximilian Schieck, Stefanie Pertschy, Sudip Kundu, Ulrich Lehmann, Bjoern Sander, Enrico Pelz, Florian Länger and 3 more

Open access · goldAbstract read
In one paragraph

Article in The journal of pathology. Clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Pitfalls in the Histological Diagnosis of Morphologic Variants of Invasive Lobular Carcinoma of the Breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Solid papillary carcinoma of the breast.Autopsy & case reports · 2022
    Review
  12. Papillary lesions of the breast.Virchows Archiv : an international journal of pathology · 2022
    Review
  13. Review
  14. Papillary neoplasms of the breast-reviewing the spectrum.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Matthias ChristgenInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Stephan BartelsInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Jana Lisa van LuttikhuizenDepartment of Human GeneticsHannover Medical SchoolHannoverGermany.
Maximilian SchieckDepartment of Human GeneticsHannover Medical SchoolHannoverGermany.ORCID 0000-0001-5878-0546
Stefanie PertschyDepartment of Diagnostic RadiologyHannover Medical SchoolHannoverGermany.
Sudip KunduDepartment of Obstetrics and GynecologyHannover Medical SchoolHannoverGermany.
Ulrich LehmannInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Bjoern SanderInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Enrico PelzInstitute of Pathology ViersenViersenGermany.
Florian LängerInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Brigitte SchlegelbergerDepartment of Human GeneticsHannover Medical SchoolHannoverGermany.
Doris SteinemannDepartment of Human GeneticsHannover Medical SchoolHannoverGermany.
Hans KreipeInstitute of Pathology, Hannover Medical SchoolHannoverGermany.
Medizinische Hochschule Hannover · DELVR-Klinik für Orthopädie Viersen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, a new variant of invasive lobular breast cancer (ILBC) with solid-papillary-like growth pattern has been described. We present a case of ILBC with solid-papillary-like growth pattern in the main tumour mass and classical invasive lobular growth pattern in adjacent satellite foci. The two tumour components were subjected to comprehensive molecular analyses. Both components were ER/PR-positive, HER2-negative, and showed a complete loss of E-cadherin and beta-catenin protein expression, as determined by immunohistochemistry. Gene expression profiling classified the main tumour and a satellite focus as luminal-B and luminal-A subtypes, respectively. Whole-genome copy number profiles were highly similar in both tumour components. Shared copy number alterations (CNAs) included gains of chromosome 1q21.1-q43 and losses of chromosome 16q11.2-q24.3, the locus of the

Indexed as

clonal evolutioncopy number profilingE‐cadherinlobular breast cancerpapillary breast cancer

Identifiers

PMID28770103
PMCPMC5527319
OpenAlexW2626552991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.