ArticleBioData mining2017
Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.
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Article in BioData mining, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed.
- Article
- Statistical inference with large-scale trait imputation.Statistics in medicine · 2024Article
- Using GWAS summary data to impute traits for genotyped individuals.HGG advances · 2023Article
- Environment-Wide Association Study (EAutism research : official journal of the International Society for Autism Research · 2020Article
- Investigation of gene-gene interactions in cardiac traits and serum fatty acid levels in the LURIC Health Study.PloS one · 2020Article
- Review
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Authors and funding
52 authors.
Emily R HolzingerComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institute for General Medical Sciences, National Institutes of Health, Baltimore, MD USA.
Shefali S VermaThe Center for Systems Genomics, The Pennsylvania State University, University Park, State College, PA USA.
Carrie B MooreDepartment of Surgery, Duke University, Durham, NC USA.
Molly HallThe Center for Systems Genomics, The Pennsylvania State University, University Park, State College, PA USA.
Rishika DeDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH USA.
Diane Gilbert-DiamondDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH USA.
Matthew B LanktreeDepartment of Medicine, McMaster University, Hamilton, ON Canada.
Nathan PankratzDepartment of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN USA.
Antoinette AmuzuLondon School of Hygiene and Tropical Medicine, London, UK.
Amber BurtDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA.
Caroline DaleLondon School of Hygiene and Tropical Medicine, London, UK.
Scott DudekThe Center for Systems Genomics, The Pennsylvania State University, University Park, State College, PA USA.
Clement E FurlongDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA.
Tom R GauntMRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Daniel Seung KimDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA.
Helene RiessInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Suthesh SivapalaratnamDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Vinicius TraganteDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Erik P A van IperenDurrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
Ariel BrautbarDepartment of Medical Genetics, Marshfield Clinic, Marshfield, WI USA.
David S CarrellGroup Health Research Institute, Group Health Cooperative, Seattle, WA USA.
David R CrosslinDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA.
Gail P JarvikDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA.
Helena KuivaniemiDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Tygerberg, South Africa.
Iftikhar J KulloDivision of Cardiovascular Diseases, Mayo Clinic, Rochester, MN USA.
Eric B LarsonGroup Health Research Institute, Group Health Cooperative, Seattle, WA USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Gerard TrompDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Tygerberg, South Africa.
Jens BaumertInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Karen J CruickshanksDepartment of Population Health Sciences, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI USA.
Martin FarrallDepartment of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Aroon D HingoraniDepartment of Epidemiology and Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK.
G K HovinghDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Barbara E KleinDepartment of Population Health Sciences, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI USA.
Ronald KleinDepartment of Population Health Sciences, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI USA.
Wolfgang KoenigDepartment of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany.
Leslie A LangeDepartment of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC USA.
Winfried MӓrzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Kari E NorthDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA.
Philippa J TalmudMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS USA.
Mika KivimakiDepartment of Epidemiology and Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK.
Meena KumariDepartment of Epidemiology and Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK.
Jason H MooreInstitute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Fotios DrenosMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Folkert W AsselbergsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Brendan J Keating *Division of Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA USA.
Marylyn D Ritchie *Biomedical and Translational Informatics, Geisinger Clinic, Danville, PA USA.
Funding
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2MVARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6MFAMILIAL AND BIRTH COHORT EFFECTS ON THE AGING SENSESR01AG021917 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CRUICKSHANKS, KAREN J · 2004 to 2018
$25.2MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MTHE EPIDEMIOLOGY OF AGE-RELATED OCULAR DISEASEU10EY006594 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, RONALD · 1987 to 2018
$17.3MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MVariation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MGenetic Epidemiology of Complex TraitsZIAHG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$10.5MEpidemiology of Age-related Hearing LossR37AG011099 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CRUICKSHANKS, KAREN J · 2009 to 2018
$7.4MBritish Heart Foundation PG/07/131/24254British Heart Foundation RG/10/12/28456Intramural NIH HHS Z01 HG000153Intramural NIH HHS Z01 HG200327Medical Research Council K013351Medical Research Council MC_UU_12013/8NCATS NIH HHS UL1 TR001422NEI NIH HHS U10 EY006594NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004599NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01 HG004609NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG008657NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL067406NHLBI NIH HHS R01 HL075366NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL095603NHLBI NIH HHS U01 HL080295NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG021917NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG032136NIA NIH HHS R37 AG011099NIA NIH HHS R37 AG013196NIA NIH HHS R56 AG020098NIGMS NIH HHS U54 GM115428NLM NIH HHS R01 LM009012NLM NIH HHS R01 LM010098
Abstract
backgroundThe genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG).
resultsOur analysis consisted of a discovery phase using a merged dataset of five different cohorts (
conclusionsThese results may reveal novel insights into the genetic etiology of lipid levels. Furthermore, we developed a pipeline to perform a computationally efficient interaction analysis with multi-cohort replication.
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Computational geneticsGenetic epidemiologyGeneticsInteractionsLipids
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