Evidence map›Paper›PMID 28769980›Full record

ArticleStem cells international2017

Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy.

Bruno Solano de Freitas Souza, Kátia Nunes da Silva, Daniela Nascimento Silva, Vinícius Pinto Costa Rocha, Bruno Diaz Paredes, Carine Machado Azevedo, Carolina Kymie Nonaka, Gisele Batista Carvalho, Juliana Fraga Vasconcelos, Ricardo Ribeiro Dos Santos and 1 more

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Galectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022
    Pooled it
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  11. Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases.International journal of molecular sciences · 2021
    Review
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  17. Article
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  19. Role of MSC-derived galectin 3 in the AML microenvironment.Biochimica et biophysica acta. Molecular cell research · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bruno Solano de Freitas SouzaGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Kátia Nunes da SilvaCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, BA, Brazil.
Daniela Nascimento SilvaCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, BA, Brazil.
Vinícius Pinto Costa RochaGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Bruno Diaz ParedesCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, BA, Brazil.
Carine Machado AzevedoGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Carolina Kymie NonakaGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Gisele Batista CarvalhoCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, BA, Brazil.
Juliana Fraga VasconcelosGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Ricardo Ribeiro Dos SantosCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, BA, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.ORCID 0000-0001-7549-2992
Hospital São Rafael · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with

Identifiers

PMID28769980
PMCPMC5523546
OpenAlexW2735675550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.