Evidence map›Paper›PMID 28769867›Full record

ArticleFrontiers in neurology2017

Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype.

Barbara Namer, Kirstin Ørstavik, Roland Schmidt, Norbert Mair, Inge Petter Kleggetveit, Maximillian Zeidler, Theresa Martha, Ellen Jorum, Martin Schmelz, Theodora Kalpachidou and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Molecular genetics and metabolism reports · 2024
    Article
  6. Dysregulation of sphingolipid metabolism in pain.Frontiers in pharmacology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Non-coding RNAs in neuropathic pain.Neuronal signaling · 2020
    Review
  17. Role of Gangliosides in Peripheral Pain Mechanisms.International journal of molecular sciences · 2020
    Review
  18. Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Barbara NamerDepartment of Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen, Germany.
Kirstin ØrstavikSection of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Roland SchmidtDepartment of Clinical Neurophysiology, Uppsala University Hospital, Uppsala, Sweden.
Norbert MairDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Inge Petter KleggetveitSection of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Maximillian ZeidlerDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Theresa MarthaDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Ellen JorumDepartment of Anesthesiology, Heidelberg University, Mannheim, Germany.
Martin SchmelzDepartment of Anesthesiology, Heidelberg University, Mannheim, Germany.
Theodora KalpachidouDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Michaela KressDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Michiel LangeslagDepartment of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATUniversität Innsbruck · ATHeidelberg University · DEOslo University Hospital · NOUniversity of Oslo · NOUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first symptom arising in many Fabry patients is neuropathic pain due to changes in small myelinated and unmyelinated fibers in the periphery, which is subsequently followed by a loss of sensory perception. Here we studied changes in the peripheral nervous system of Fabry patients and a Fabry mouse model induced by deletion of α-galactosidase A (Gla

Indexed as

electrophysiologyFabry diseaselysosomal storage disorderneuronal excitabilitynociceptionsingle fiber recordings

Identifiers

PMID28769867
PMCPMC5510289
OpenAlexW2735540378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.