ReviewFrontiers in neurology2017
Eyelid Dysfunction in Neurodegenerative, Neurogenetic, and Neurometabolic Disease.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Article
- Amantadine Can Treat Blepharospasm in Levodopa Peak-Dose Dyskinesia.Movement disorders clinical practice · 2025Article
- Rhythmic Eyelid Closure Responsive to STN-DBS: Blepharoclonus, Blepharospasm, Eyelid Opening Apraxia, or Eyelid Tremor?Movement disorders clinical practice · 2025Article
- Video-based analysis of the blink reflex in Parkinson's disease patients.Biomedical engineering online · 2024Article
- Machine Learning and Digital Biomarkers Can Detect Early Stages of Neurodegenerative Diseases.Sensors (Basel, Switzerland) · 2024Review
- Alternating unilateral blepharospasm with apraxia of eyelid opening in a patient with progressive supranuclear palsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- A Focus on Myasthenic Ptosis: The Interface of Medical and Surgical Treatment.World journal of plastic surgery · 2024Review
- Integrative Assessment for Optimizing Aesthetic Outcomes When Treating Glabellar Lines With Botulinum Toxin Type A: An Appreciation of the Role of the Frontalis.Aesthetic surgery journal · 2023Review
- Eyelid Nystagmus and Other Involuntary Movements of the Upper Lids; What's in a Name?Movement disorders clinical practice · 2023Article
- Narrative Review Concerning the Clinical Spectrum of Ophthalmological Impairments in Parkinson's Disease.Neurology international · 2023Review
- Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies.Drugs in context · 2023Article
- Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury.IEEE reviews in biomedical engineering · 2023Review
- Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Effect of Muller's muscle-conjunctival resection on the upper eyelid crease position in Asian eyelids: a retrospective cohort study.BMC ophthalmology · 2022Article
- Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs.Molecules (Basel, Switzerland) · 2022Review
- Understanding Parinaud's Syndrome.Brain sciences · 2021Review
- An Eye on Movement Disorders.Movement disorders clinical practice · 2021Review
- A review of acquired blepharoptosis: prevalence, diagnosis, and current treatment options.Eye (London, England) · 2021Review
- A Curious Case of Excessive Winking.Movement disorders clinical practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eye movement abnormalities are among the earliest clinical manifestations of inherited and acquired neurodegenerative diseases and play an integral role in their diagnosis. Eyelid movement is neuroanatomically linked to eye movement, and thus eyelid dysfunction can also be a distinguishing feature of neurodegenerative disease and complements eye movement abnormalities in helping us to understand their pathophysiology. In this review, we summarize the various eyelid abnormalities that can occur in neurodegenerative, neurogenetic, and neurometabolic diseases. We discuss eyelid disorders, such as ptosis, eyelid retraction, abnormal spontaneous and reflexive blinking, blepharospasm, and eyelid apraxia in the context of the neuroanatomic pathways that are affected. We also review the literature regarding the prevalence of eyelid abnormalities in different neurologic diseases as well as treatment strategies (Table 1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.