Evidence map›Paper›PMID 28769790›Full record

ArticleFrontiers in pharmacology2017

Phenotypic Screening Identifies Synergistically Acting Natural Product Enhancing the Performance of Biomaterial Based Wound Healing.

Srinivasan Sivasubramanian, Gayathri Chandrasekar, Sara Svensson Akusjärvi, Ramar Thangam, Malairaj Sathuvan, R B S Kumar, Hawraa Hussein, Savariar Vincent, Balaraman Madhan, Palani Gunasekaran and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Srinivasan SivasubramanianDepartment of Virology, King Institute of Preventive Medicine and ResearchChennai, India.
Gayathri ChandrasekarDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetSolna, Sweden.
Sara Svensson AkusjärviDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetSolna, Sweden.
Ramar ThangamDepartment of Virology, King Institute of Preventive Medicine and ResearchChennai, India.
Malairaj SathuvanDepartment of Virology, King Institute of Preventive Medicine and ResearchChennai, India.
R B S KumarDepartment of Virology, King Institute of Preventive Medicine and ResearchChennai, India.
Hawraa HusseinDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetSolna, Sweden.
Savariar VincentCenter for Environmental Research and Development, Loyola Institute of Frontier Energy, Loyola CollegeChennai, India.
Balaraman MadhanCouncil of Scientific and Industrial Research - Central Leather Research InstituteChennai, India.
Palani GunasekaranDepartment of Virology, King Institute of Preventive Medicine and ResearchChennai, India.
Satish S KitambiDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetSolna, Sweden.
Karolinska Institutet · SEKing Institute of Preventive Medicine and Research · INCouncil of Scientific and Industrial Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an affordable strategy to develop dressing material with high efficiency in healing wounds. Using image based phenotyping and quantification, we screened natural product derived bioactive compounds for modulators of types I and III collagen production from human foreskin derived fibroblast cells. The identified hit was then formulated with amnion to develop a biomaterial, and its biophysical properties,

Indexed as

amnionbiomarkersbiomaterialsnatural productsPDDphenotypic screeningwound

Identifiers

PMID28769790
PMCPMC5513901
OpenAlexW2736266076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.