Evidence map›Paper›PMID 28769782›Full record

ArticleFrontiers in aging neuroscience2017

Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice.

Nicholas W DeKorver, Tammy R Chaudoin, Stephen J Bonasera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas W DeKorverDivision of Geriatrics, Department of Internal Medicine, Durham Research Center II, University of Nebraska Medical CenterOmaha, NE, United States.
Tammy R ChaudoinDivision of Geriatrics, Department of Internal Medicine, Durham Research Center II, University of Nebraska Medical CenterOmaha, NE, United States.
Stephen J BonaseraDivision of Geriatrics, Department of Internal Medicine, Durham Research Center II, University of Nebraska Medical CenterOmaha, NE, United States.
University of Nebraska Medical Center · US

Funding

Modifying age-related changes in mouse neuroinflammation & functional behaviorsR01AG031158 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BONASERA, STEPHEN J · 2009 to 2013
$2.9M
NIA NIH HHS R01 AG031158
6 · The paper itself

Abstract

Regulatory systems required to maintain behavioral arousal remain incompletely understood. We describe a previously unappreciated role that toll-like receptor 2 (Tlr2, a membrane bound pattern recognition receptor that recognizes specific bacterial, viral, and fungal peptides), contributes toward regulation of behavioral arousal. In 4-4.5 month old mice with constitutive loss of Tlr2 function (Tlr2

Indexed as

active/inactive state consolidationcircadian behaviorhome cage behaviormovementsleep fragmentationTlr2 knockout mouse

Identifiers

PMID28769782
PMCPMC5510442
OpenAlexW2736072019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.