ArticleClinical interventions in aging2017
Increased neutrophil-lymphocyte ratio in delirium: a pilot study.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as prognostic predictors for delirium in critically ill patients: a systematic review and meta-analysis.BMC anesthesiology · 2023Pooled it
- A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes.BMC psychiatry · 2020Pooled it
- Article
- A nomogram model to predict postoperative delirium in esophageal cancer patients undergoing esophagectomy.BMC cancer · 2025Article
- Comparative analysis of four nutritional scores in predicting delirium in ICU patients.Frontiers in nutrition · 2025Article
- Can Neutrophil-to-Lymphocyte Ratio, Platelet Volume, and Platelet Distribution Width Be Used as Indicators of Delirium?Journal of clinical medicine · 2024Article
- Article
- Delirium in the ICU: how much do we know? A narrative review.Annals of medicine · 2024Review
- How to predict postoperative delirium in geriatric patients with hip fracture as soon as possible? A retrospective study.BMC surgery · 2024Article
- Immunological Analysis of Postoperative Delirium after Thoracic Aortic Surgery.Journal of chest surgery · 2024Article
- Association of preoperative neutrophil-lymphocyte ratios with the emergence delirium in pediatric patients after tonsillectomy and adenoidectomy: an observational prospective study.Journal of anesthesia · 2024Observational
- Relationship between preoperative neutrophil-to-lymphocyte ratio and postoperative delirium: The PNDABLE and the PNDRFAP cohort studies.Brain and behavior · 2023Article
- Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia?Aging clinical and experimental research · 2022Article
- Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia?Aging clinical and experimental research · 2022Article
- Challenges in the Detection of Clinically Useful Biomarkers for the Diagnosis of Delirium in Older People in the Emergency Department-A Case-Control Study.Life (Basel, Switzerland) · 2022Article
- Preoperative Inflammatory Markers and the Risk of Postoperative Delirium in Patients Undergoing Lumbar Spinal Fusion Surgery.Journal of clinical medicine · 2022Article
- Automated machine learning-based model predicts postoperative delirium using readily extractable perioperative collected electronic data.CNS neuroscience & therapeutics · 2022Observational
- Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank.Translational psychiatry · 2021Article
- Delirium Severely Worsens Outcome in Patients with COVID-19-A Retrospective Cohort Study from Temporary Critical Care Hospitals.Journal of clinical medicine · 2021Article
- Neutrophil-lymphocyte ratio as a predictor of delirium in older internal medicine patients: a prospective cohort study.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimDelirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil-lymphocyte ratio (NLR) - a marker of systemic inflammation and oxidative stress - in patients with and without delirium.
methodsThis pilot study was performed within a retrospective chart review study that included acutely ill patients, 65 years and older, who were admitted to the ward of geriatrics of the Erasmus University Medical Center. All patients in whom the differential white blood cell (WBC) counts as well as the C-reactive protein (CRP) level were determined within 24 h after admission were included in the present study. Differences in NLR between patients with and without delirium were investigated using univariate analysis of variance, with adjustments for age, sex, comorbidities, CRP level, and total WBC count.
resultsEighty-six patients were included. Thirteen patients were diagnosed with delirium. In adjusted models, higher mean NLR values were found in patients with, than in those without, delirium (9.10 vs 5.18,
conclusionIn this pilot study, we found increased NLR levels in patients with delirium. This finding might suggest that an inadequate response of the immune system and oxidative stress may play a role in the pathogenesis of delirium. Further studies are needed to confirm the association between NLR and delirium.
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