ArticleShanghai archives of psychiatry2017
Relationship of Mean Platelet Volume To MDD: A Retrospective Study.
Article in Shanghai archives of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association of platelet-to-lymphocyte ratio with depression risk: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Meta-analysis of peripheral mean platelet volume in patients with mental disorders: Comparisons in depression, anxiety, bipolar disorder, and schizophrenia.Brain and behavior · 2023Pooled it
- Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse.Molecular psychiatry · 2026Article
- Analysis of complete blood counts and derived inflammatory indices with non-suicidal self-injury and suicide attempt in adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
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- Article
- A novel joint index based on peripheral blood CD4+/CD8+ T cell ratio, albumin level, and monocyte count to determine the severity of major depressive disorder.BMC psychiatry · 2022Article
- Changes in leukocytes and CRP in different stages of major depression.Journal of neuroinflammation · 2022Article
- Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders.BMC psychiatry · 2022Article
- Impact of depression on the quality of sleep and immune functions in patients with coronary artery disease.General psychiatry · 2022Article
- Platelet Parameters, C-Reactive Protein, and Depression: An Association Study.International journal of general medicine · 2022Article
- Blood Count Parameters as Inflammation Indicators in Children and Adolescents Diagnosed with Depressive Disorder.Psychiatry and clinical psychopharmacology · 2021Article
- Association of the neutrophil to lymphocyte ratio and white blood cell count with response to pharmacotherapy in unipolar psychotic depression: An exploratory analysis.Brain, behavior, & immunity - health · 2021Article
- Potential major depressive disorder biomarkers in pediatric population - a pilot study.Physiological research · 2020Article
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments.BMC medicine · 2020Review
- Revisiting the link between platelets and depression through genetic epidemiology: new insights from platelet distribution width.Haematologica · 2020Article
- Elevated neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict post-stroke depression with acute ischemic stroke.Experimental and therapeutic medicine · 2020Article
- The Association between Neutrophil-to-Lymphocyte Ratio and Diabetic Depression in U.S. Adults with Diabetes: Findings from the 2009-2016 National Health and Nutrition Examination Survey (NHANES).BioMed research international · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResults of numerous studies show that major depressive disorder (MDD) is associated with a chronic low-grade inflammation, but the underlying mechanism remains unclear.
aimTo compare the results of blood cell analysis of MDD patients with healthy controls, and explore the potential value of it as an indicator of immune-inflammation in MDD, especially the mean platelet volume.
methods103 MDD patients and 106 healthy controls with matched age and gender were recruited. We collected peripheral blood samples from both groups and gathered basic data. For comparison of normally distributed data (age, body mass index, lymphocyte count, white blood cell count, red blood cell count, hematocrit, platelet count and mean corpuscular volume) between groups, single t-test were used; and for comparison of non-normally distributed data (Neutrophil count, neutrophil count, platelet/ lymphocyte ratio, hemoglobin, red blood cell distribution width, mean platelet volume, mean hemoglobin concentration, mean hemoglobin and platelet distribution width), we used Mann-Whitney U-test.
resultsCompared with healthy controls, the MDD groups showed significantly higher white blood cell count (
conclusionsThe results suggest that serum inflammatory response probably exists in people with MDD, and indicators of blood analysis especially mean platelet volume have a potential value as biomarker for inflammation.
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