Evidence map›Paper›PMID 28769538›Full record

ArticleMediators of inflammation2017

Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway.

Orlei Ribeiro de Araujo, Reinaldo Salomão, Milena Karina Coló Brunialti, Dafne Cardoso Bourguignon da Silva, Andreza Almeida Senerchia, Fabianne Altruda de Moraes Costa Carlesse, Antonio Sergio Petrilli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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  11. T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Orlei Ribeiro de AraujoGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, Brazil.ORCID 0000-0001-8230-6801
Reinaldo SalomãoDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 669, 10th Floor, 04039-001 São Paulo, SP, Brazil.
Milena Karina Coló BrunialtiDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 669, 10th Floor, 04039-001 São Paulo, SP, Brazil.
Dafne Cardoso Bourguignon da SilvaGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, Brazil.
Andreza Almeida SenerchiaGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, Brazil.
Fabianne Altruda de Moraes Costa CarlesseGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, Brazil.
Antonio Sergio PetrilliGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, Brazil.
Support group for adolescents and children with cancer · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis.

methodsIL-1

resultsThirteen patients (37.1%) developed sepsis. In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (

conclusionsCytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.

Indexed as

BiomarkersCytokinesFilgrastimGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-10Interleukin-12Interleukin-17Interleukin-23Interleukin-6Interleukin-8KineticsSepsisSignal TransductionBiomarkersCytokinesFilgrastimGranulocyte-Macrophage Colony-Stimulating FactorIL17A protein, humanInterleukin-10Interleukin-12Interleukin-17Interleukin-23Interleukin-6Interleukin-8

Identifiers

PMID28769538
PMCPMC5523193
OpenAlexW2732011840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.