ArticleScientific reports2017
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Ambient temperature regulates CD4iScience · 2026Article
- The effects of housing temperature on mouse physiology and implications for disease modeling.Lab animal · 2026Review
- Impact of airflow stimulation: mild cold airflow is more sensitive to influenza virus infection.Journal of thoracic disease · 2025Article
- Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1.Frontiers in immunology · 2025Article
- Molecular connections between inflammation and social determinants of health.Frontiers in epidemiology · 2025Review
- Obesity amplifies influenza virus-driven disease severity in male and female mice.Mucosal immunology · 2023Article
- Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases.Nutrients · 2023Article
- Article
- How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress.Temperature (Austin, Tex.) · 2023Review
- Assessing the indoor air quality and their predictor variable in 21 home offices during the Covid-19 pandemic in Norway.Building and environment · 2022Article
- Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility.Animals : an open access journal from MDPI · 2022Review
- IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.Frontiers in immunology · 2022Review
- Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery.BMC immunology · 2020Review
- A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1/Th2 Immune Responses in Mice.Journal of immunology research · 2020Article
- Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?Frontiers in immunology · 2020Review
- Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.
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