ArticleScientific reports2017
Long-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Redox regulation of memory formation by Rrp1 inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A memory transcriptome time course reveals essential long-term memory transcription factors.Nature communications · 2025Article
- Hybrid neural networks in the mushroom body drive olfactory preference inScience advances · 2025Article
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- Roles of feedback and feed-forward networks of dopamine subsystems: insights fromLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Forgotten memory storage and retrieval in Drosophila.Nature communications · 2023Article
- Independent insulin signaling modulators govern hot avoidance under different feeding states.PLoS biology · 2023Article
- Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research.Genetics · 2023Article
- Article
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.The European journal of neuroscience · 2022Article
- Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation.Trends in neurosciences · 2022Review
- Article
- Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation iniScience · 2021Article
- Article
- CREBA and CREBB in two identified neurons gate long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.Cell reports · 2021Article
- Transsynaptic mapping ofeLife · 2021Article
- Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.Nature communications · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic changes in the brain. In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labile memory to associate an odor with coincident punishment in the mushroom body (MB). It remains unclear how the brain consolidates early labile memory into LTM. Here, we survey 183 Gal4 lines containing almost all 21 distinct types of MB output neurons (MBONs) and show that sequential synthesis of learning-induced proteins occurs at three types of MBONs. Downregulation of oo18 RNA-binding proteins (ORBs) in any of these MBONs impaired LTM. And, neurotransmission outputs from these MBONs are all required during LTM retrieval. Together, these results suggest an LTM consolidation model in which transient neural activities of early labile memory in the MB are consolidated into stable LTM at a few postsynaptic MBONs through sequential ORB-regulated local protein synthesis.
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